HLA-A25 (A25) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α25 subset of HLA-A α-chains. For A25, the alpha "A" chain are encoded by the HLA-A*25 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2501. A25 and A*25 are almost synonymous in meaning. A25 is a split antigen of the broad antigen serotype A10. A25 is a sister serotype of A26, A34, A43, and A66.
| HLA-A25 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (MHC Class I, A cell surface antigen) | ||||||||||||||||
 HLA-A25 | ||||||||||||||||
| About | ||||||||||||||||
| Protein | transmembrane receptor/ligand | |||||||||||||||
| Structure | αβ heterodimer | |||||||||||||||
| Subunits | HLA-A*2501, β2-microglobulin | |||||||||||||||
| Older names | A10 | |||||||||||||||
| Subtypes | ||||||||||||||||
| ||||||||||||||||
| Alleles link-out to IMGT/HLA database at EBI | ||||||||||||||||
A25 is more common in SW Asia to NW Europe. A25 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].
Serotype
edit| A*25 | A25 | A10 | Sample |
| allele | % | % | size (N) |
| *2501 | 95 | 2 | 1375 |
A25 reasonably good serotyping with no overt false recognition..
A25 frequencies
edit| Study population | Freq. (in %)[4] |
|---|---|
| Saudi Arabia | 5.7 |
| India Jalpaiguri Toto | 5.1 |
| Russia Northwest | 5.1 |
| Serbia | 4.8 |
| Spain Pas Valley | 4.3 |
| Czech Republic | 4.2 |
| Spain North Cantabrian | 4.2 |
| Russia Arkhangelsk Pomors | 4.0 |
| Spain North Cabuernigo | 3.8 |
| Ireland South | 3.6 |
| Romanian | 3.5 |
| USA Caucasians (3) | 3.4 |
| Croatia | 3.0 |
| Bulgaria | 2.7 |
| Spain Basque Arratia Vall… | 2.7 |
| Sweden Uppsala County | 2.5 |
| Scotland Orkney | 2.5 |
| German Essen | 2.4 |
| Wales | 2.1 |
| Argentina Buenos Aires | 2.0 |
| Ireland Northern | 2.0 |
| Morocco | 2.0 |
| Spain Eastern Andalusia | 2.0 |
| Australia New South Wales | 1.9 |
| Georgia Svaneti Svans | 1.9 |
| Italy | 1.9 |
| Macedonia | 1.9 |
| Sweden Stockholm | 1.9 |
| England Liverpool | 1.9 |
| Azores Central Islands | 1.8 |
| Turkey | 1.8 |
| England Lancaster | 1.8 |
| England Sheffield | 1.6 |
| Israeli Jews | 1.5 |
| Spain Basque Gipuzkoa Pro… | 1.5 |
| Italy South Campania | 1.2 |
| New Caledonia | 1.2 |
| Uganda Kampala | 1.2 |
| Australia West | 1.1 |
| Finland | 1.1 |
| Portugal Centre (2) | 1.1 |
| Spain Catalonia Girona | 1.1 |
| Belgium | 1.0 |
| France Corsica | 1.0 |
| Mongolia Oold | 1.0 |
| Russia Murmansk Saomi | 1.0 |
| Russia Sakhalin Island Ni… | 0.9 |
| France South East | 0.8 |
| USA South Texas Hispanics | 0.8 |
| Morocco 'Berber' Nador Me… | 0.7 |
| USA South Dakota Lakota S… | 0.7 |
| Greece | 0.6 |
| USA Arizona Pima | 0.6 |
| Algeria1 | 0.5 |
| China Qinghai Hui | 0.5 |
| Allele frequencies presented, only | |
A*2501 distribution is primarily located in Western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.
References
edit- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
- ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ^ Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.