ZDHHC17

Palmitoyltransferase ZDHHC17 is an enzyme that contains a DHHC domain that in humans is encoded by the ZDHHC17 gene.

ZDHHC17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EU9
Identifiers
Aliases	ZDHHC17, HIP14, HIP3, HYPH, HSPC294, zinc finger DHHC-type containing 17, DHHC-17, zinc finger DHHC-type palmitoyltransferase 17, DHHC17
External IDs	OMIM: 607799; MGI: 2445110; HomoloGene: 56324; GeneCards: ZDHHC17; OMA:ZDHHC17 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q21.2 Start 76,764,103 bp End 76,853,696 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D1 Start 110,777,641 bp End 110,846,001 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum cerebellar vermis Brodmann area 23 lateral nuclear group of thalamus external globus pallidus pars compacta superior vestibular nucleus pars reticulata subthalamic nucleus pons Top expressed in neural layer of retina gastrula Rostral migratory stream lobe of cerebellum cerebellar vermis ascending aorta nucleus of stria terminalis otolith organ inferior colliculi utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-cysteine S-palmitoyltransferase activity transferase activity magnesium ion transmembrane transporter activity signal transducer activity palmitoyltransferase activity protein binding identical protein binding acyltransferase activity Cellular component integral component of membrane Golgi apparatus intracellular membrane-bounded organelle membrane Golgi membrane Golgi-associated vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle presynaptic membrane plasma membrane synapse cell junction cytosol Biological process protein palmitoylation positive regulation of I-kappaB kinase/NF-kappaB signaling lipoprotein transport signal transduction magnesium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23390 320150 Ensembl ENSG00000186908 ENSMUSG00000035798 UniProt Q8IUH5 Q80TN5 RefSeq (mRNA) NM_015336 NM_001359626 NM_172554 NM_001359622 NM_001359624 RefSeq (protein) NP_056151 NP_001346555 NP_766142 NP_001346551 NP_001346553 Location (UCSC) Chr 12: 76.76 – 76.85 Mb Chr 10: 110.78 – 110.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ZDHHC17 has been shown to interact with Huntingtin.

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD (Dec 2004). "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase". Oncogene. 23 (57): 9230–7. doi:10.1038/sj.onc.1208171. PMC 2908390. PMID 15489887.
• Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A (Dec 2004). "Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins". Neuron. 44 (6): 977–86. doi:10.1016/j.neuron.2004.11.027. PMID 15603740. S2CID 14406733.