William A. Graham may refer to:
- William Alexander Graham (1804–1875), American politician; Whig from North Carolina
- William A. Graham (agriculture commissioner) (1839–1923), American politician and Civil War veteran
- William A. Graham (director) (1926–2013), American television and film director
- William A. Graham (dean) (born 1943), dean of Harvard Divinity School from 2002 to 2012