Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.[1][2][3]
Function
editThe Dmrt1 gene is believed to be part of the sex-determination pathway in invertebrates, mammals and birds[4][5][6] Dmrt1 contains a zinc finger-like DNA-binding motif (DM domain) that is also present in the sex-determination genes doublesex of flies and mab-3 of nematodes. The DNA-binding motif is an ancient conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes, and is found to be the key sex-determining factor in chickens.[6] This gene exhibits a gonad-specific and sexually dimorphic expression pattern, just like the related doublesex gene in fruit flies. Defective testicular development and XY feminization occur when this gene is hemizygous.[1]
References
edit- ^ a b "Entrez Gene: DMRT1 doublesex and mab-3 related transcription factor 1".
- ^ Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). "Evidence for evolutionary conservation of sex-determining genes". Nature. 391 (6668): 691–5. doi:10.1038/35618. PMID 9490411.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ Raymond CS, Parker ED, Kettlewell JR, Brown LG, Page DC, Kusz K, Jaruzelska J, Reinberg Y, Flejter WL, Bardwell VJ, Hirsch B, Zarkower D (June 1999). "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators". Hum. Mol. Genet. 8 (6): 989–96. doi:10.1093/hmg/8.6.989. PMID 10332030.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ Raymond CS, Kettlewell JR, Hirsch B, Bardwell VJ, Zarkower D (1999). "Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development". Dev Biol. 215 (2): 208–20. doi:10.1006/dbio.1999.9461. PMID 10545231.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Murphy MW, Sarver AL, Rice D, Hatzi K, Ye K, Melnick A; et al. (2010). "Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis". Proc Natl Acad Sci U S A. 107 (30): 13360–5. doi:10.1073/pnas.1006243107. PMC 2922116. PMID 20616082.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ a b Smith CA, Roeszler KN, Ohnesorg T, Cummins DM, Farlie PG, Doran TJ, Sinclair AH (August 2009). "The avian Z-linked gene DMRT1 is required for male sex determination in the chicken". Nature. 461 (7261): 267–71. doi:10.1038/nature08298. PMID 19710650.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)
Further reading
editExternal links
edit- DMRT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- http://www.dmrt1.umn.edu