Mbandla

Zaren's Peer review

Everything looks great because lots of new material was added

The sources are good and the information seems accurate

I like the images and how all the given information is easy to locate

I'm not sure of the necessity of the cAMP section but I do see your reasoning with including it

I think the terminology used wasn't too technical so continue with that style

Peer Review from Weiye:

Overall, I think this article is pretty clear and well supported. Here are a few of my suggestions and comments on the section you added:

• Can you find one or two sources backing up your statement of "other studies suggest that the hight ratio of..."? It might be helpful for someone looking for information from that aspect.
• The wording "protects AMPK against inactivation" sounds a bit more complicated than necessary in my opinion. I think it's more straightforward to simply say "helps activating AMPK", but I get it that you are trying to contrast with the inactivation process mentioned before.

• The last paragraph in the second section doesn't seem to be very related to this topic to me, but I guess that you are trying to connect metabolism regulation with AMPK enzyme. I suggest either go a bit further after the existing sentence, or restate this sentence to make direct comments about how AMPK and AMP are playing their roles in energy charge regulation. Or maybe add another section talking about this for AMP only, like the energy charge questions we encountered in lectures and homework but in more depth.

I can see from the history view that you didn't add much information in the other sections, but when reading those, I just found two things that I want to point out:

• Cyclic AMP sounds very interesting to me, but I think it might be more helpful to visualize cAMP with a picture. Also, this section is missing proper references.
• The last 2 equations in the first section confuse me a bit. So according to the equation showing AMP being converted into ADP, an ATP is used rather than just adding pi to AMP. Can you find studies about this?

Adenosine monophosphate: more room for expansion than cAMP, particularly its role in regulatin

Role in AMP-activated kinase regulation

The eukaryotic cell enzyme 5' adenosine monophosphate-activated protein kinase, or AMPK, utilizes AMP for homeostatic energy processes. AMPK is activated by decreasing levels of ATP, which also results in increasing levels of ADP and AMP.