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This is proposed wording to add to the "Causes of autism" article. This would go in the "Related disorders" section.
Studies indicate that mitochondrial dysfunction, a set of disorders in which mitochondria fail to produce energy sufficient for cell or organ function,[1] is not rare in people with autism spectrum disorder.[2][3] (Mitochondrial dysfunction as a cause of autism spectrum disorder had been proposed as a hypothesis in 1998.[4]) In 2011, the Immunization Safety Office (ISO) of the Centers for Disease Control and Prevention (CDC) included as a "high priority" in its five-year scientific agenda the need to investigate whether immunization is "associated with increased risk for neurological deterioration in children with mitochondrial disorders."[5] A precedent was the 2010 settlement[6] of the Hannah Poling case,[7] in which it had been alleged that the MMR vaccine had significantly aggravated a child's pre-existing mitochondrial disorder, with the presumptive injury of encephalopathy eventually manifesting "as a chronic encephalopathy with features of autism spectrum disorder" and other sequelae.(cite court case)[8] The scientific agenda document described ongoing investigations. The agenda item's goal was that the Clinical Immunization Safety Assessment project (CISA) would "develop guidelines for clinical investigations of individual adverse events following immunizations that might occur in children with underlying mitochondrial disorders."[5] In (year), the Immunization Research Office stated that (paraphrase or quote its conclusions about any relationship between vaccinations and autism spectrum disorder.)(add cite) Numerous cases in the Office of Special Masters of the United States Court of Federal Claims, also known as "Vaccine Court," have failed to prove (describe proper standard) that vaccinating a person with mitochondrial dysfunction caused autism spectrum disorder.(cite)
Make a transition to next paragraph about environmental influences.
[Need to notify people on talk page that I am working on this draft.]
- ^ "About Mitochondrial Disease - Mito FAQ". mitoaction.org. Retrieved November 26, 2018.
- ^ Rossignol, D.A.; Frye, R.E. (March 2012). "Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis". Molecular Psychiatry. 17 (3): 290–314. doi:10.1038/mp.2010.136. PMC 3285768. PMID 21263444.
- ^ Rose, Shannon; Niyazov, Dimitriy M.; Rossignol, Daniel A.; Goldenthal, Michael; Kahler, Stephen G.; Frye, Richard E. (2018). "Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder". Molecular Diagnosis & Therapy. 22 (5): 571–593. doi:10.1007/s40291-018-0352-x. PMC 6132446. PMID 30039193.
- ^ Lombard, J. (June 1998). "Autism: a mitochondrial disorder?". Medical Hypotheses. 50 (6): 497–500. doi:10.1016/S0306-9877(98)90270-5. PMID 9710323. Retrieved November 25, 2018.
- ^ a b "Centers for Disease Control and Prevention's Immunization Safety Office Scientific Agenda" (PDF). cdc.gov. February 2011. p. 31. Retrieved November 26, 2018.
- ^ Fix this-https://uscfc.uscourts.gov/sites/default/files/opinions/CAMPBELLSMITH.%20DOE77082710.pdf
- ^ Poling, John S.; Frye, Richard E.; Shoffner, John; Zimmerman, Andrew W. (February 2006). "Developmental Regression and Mitochondrial Dysfunction in a Child With Autism". Journal of Child Neurology. 21 (12): 170–172. doi:10.1177/08830738060210021401. PMC 2536523. PMID 16566887.
- ^ fix this - https://www.cbsnews.com/news/family-to-receive-15m-plus-in-first-ever-vaccine-autism-court-award/