In enzymology, an ubiquitin-calmodulin ligase (EC 6.3.2.21) is an enzyme that catalyzes the chemical reaction
| ubiquitin-calmodulin ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.2.21 | ||||||||
| CAS no. | 119632-60-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- n ATP + calmodulin + n ubiquitin n AMP + n diphosphate + (ubiquitin)n-calmodulin
The 3 substrates of this enzyme are ATP, calmodulin, and ubiquitin, whereas its 3 products are AMP, diphosphate, and (ubiquitin)n-calmodulin.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is calmodulin:ubiquitin ligase (AMP-forming). Other names in common use include ubiquityl-calmodulin synthase, ubiquitin-calmodulin synthetase, ubiquityl-calmodulin synthetase, and uCaM-synthetase.
References
edit- Jennissen HP, Laub M (1988). "Ubiquitin-calmodulin conjugating activity from cardiac muscle". Biol. Chem. Hoppe-Seyler. 369 (12): 1325–30. doi:10.1515/bchm3.1988.369.2.1325. PMID 2853950.
- Ziegenhagen R, Jennissen HP (1988). "Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase". Biol. Chem. Hoppe-Seyler. 369 (12): 1317–24. doi:10.1515/bchm3.1988.369.2.1317. PMID 2853949.
