Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.[5][6]

USP16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUSP16, UBP-M, UBPM, ubiquitin specific peptidase 16
External IDsOMIM: 604735; MGI: 1921362; HomoloGene: 38183; GeneCards: USP16; OMA:USP16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006447
NM_001001992
NM_001032410

NM_024258

RefSeq (protein)

NP_001001992
NP_001027582
NP_006438

NP_077220

Location (UCSC)Chr 21: 29.02 – 29.05 MbChr 16: 87.45 – 87.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156256Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025616Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ a b "Entrez Gene: USP16 ubiquitin specific peptidase 16".

Further reading

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