UBE2R2

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

UBE2R2
Identifiers
Aliases	UBE2R2, CDC34B, E2-CDC34B, UBC3B, ubiquitin conjugating enzyme E2 R2
External IDs	OMIM: 612506; MGI: 1914865; HomoloGene: 3210; GeneCards: UBE2R2; OMA:UBE2R2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 33,817,160 bp End 33,920,399 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 41,135,743 bp End 41,193,380 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte mucosa of ileum myocardium of left ventricle tibialis anterior muscle cardiac muscle tissue of right atrium nipple skin of arm Skeletal muscle tissue of rectus abdominis decidua Top expressed in genital tubercle tail of embryo blood ascending aorta aortic valve Rostral migratory stream internal carotid artery lactiferous gland muscle of thigh external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol Biological process protein K48-linked ubiquitination protein monoubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination protein polyubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54926 67615 Ensembl ENSG00000107341 ENSMUSG00000036241 UniProt Q712K3 Q6ZWZ2 RefSeq (mRNA) NM_017811 NM_026275 RefSeq (protein) NP_060281 NP_080551 Location (UCSC) Chr 9: 33.82 – 33.92 Mb Chr 4: 41.14 – 41.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.