UBE2J1

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.

UBE2J1
Identifiers
Aliases	UBE2J1, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, Ubc6p, CGI-76, UBC6E, ubiquitin conjugating enzyme E2 J1
External IDs	OMIM: 616175; MGI: 1926245; HomoloGene: 41090; GeneCards: UBE2J1; OMA:UBE2J1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q15 Start 89,326,625 bp End 89,352,722 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 33,031,416 bp End 33,052,363 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm monocyte bone marrow cells parotid gland rectum epithelium of nasopharynx amniotic fluid tonsil appendix lymph node Top expressed in seminiferous tubule lacrimal gland ectoderm otic vesicle otic placode saccule facial motor nucleus anterior horn of spinal cord spermatid medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ATP binding ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin conjugating enzyme activity Cellular component cytoplasm membrane integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum Biological process protein N-linked glycosylation via asparagine protein ubiquitination ubiquitin-dependent ERAD pathway spermatid development negative regulation of retrograde protein transport, ER to cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51465 56228 Ensembl ENSG00000198833 ENSMUSG00000028277 UniProt Q9Y385 Q9JJZ4 RefSeq (mRNA) NM_016021 NM_019586 NM_001355494 RefSeq (protein) NP_057105 NP_062532 NP_001342423 Location (UCSC) Chr 6: 89.33 – 89.35 Mb Chr 4: 33.03 – 33.05 Mb PubMed search
Wikidata
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Lenk U, Yu H, Walter J, et al. (2002). "A role for mammalian Ubc6 homologues in ER-associated protein degradation". J. Cell Sci. 115 (Pt 14): 3007–14. doi:10.1242/jcs.115.14.3007. PMID 12082160.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wu CJ, Conze DB, Li X, et al. (2005). "TNF-α induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination". EMBO J. 24 (10): 1886–98. doi:10.1038/sj.emboj.7600649. PMC 1142588. PMID 15861135.
• Oh RS, Bai X, Rommens JM (2006). "Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress". J. Biol. Chem. 281 (30): 21480–90. doi:10.1074/jbc.M601843200. PMID 16720581.