Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene .[ 5] [ 6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes : ubiquitin-activating enzymes , or E1s, ubiquitin-conjugating enzymes , or E2s, and ubiquitin-protein ligases , or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes . Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[ 6]
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