A panorama of the St. Louis, Missouri skyline, as seen from across the Mississippi River in East St. Louis, Illinois, centered on the Gateway Arch. The Arch, as the centerpiece of the Gateway Arch National Park, sits near the starting point of the Lewis and Clark Expedition, and commemorates the Louisiana Purchase, the first civil government west of the Mississippi, and the debate over slavery raised by the Dred Scott case.Photo credit: Brian Uphoff