| Pos | Div | Team | Pld | W | SOW | SOL | L | GF | GA | GD | Pts | Qualification |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | FR | St. Louis City 2 | 24 | 15 | 1 | 2 | 6 | 51 | 34 | +17 | 49 | Qualification for the 2022 MLS Next Pro Playoffs |
| 2 | PC | Tacoma Defiance | 24 | 14 | 3 | 1 | 6 | 57 | 25 | +32 | 49 | |
| 3 | FR | Houston Dynamo 2 | 24 | 14 | 2 | 3 | 5 | 38 | 22 | +16 | 49 | |
| 4 | FR | North Texas SC | 24 | 13 | 2 | 3 | 6 | 48 | 31 | +17 | 46 | |
| 5 | PC | San Jose Earthquakes II | 24 | 12 | 1 | 3 | 8 | 48 | 37 | +11 | 41 | |
| 6 | FR | Minnesota United FC 2 | 24 | 9 | 4 | 1 | 10 | 43 | 39 | +4 | 36 | |
| 7 | PC | Whitecaps FC 2 | 24 | 7 | 3 | 5 | 9 | 40 | 40 | 0 | 32 | |
| 8 | FR | Sporting Kansas City II | 24 | 9 | 1 | 2 | 12 | 31 | 38 | −7 | 31 | |
| 9 | FR | Colorado Rapids 2 | 24 | 7 | 4 | 2 | 11 | 33 | 56 | −23 | 31 | |
| 10 | PC | Real Monarchs | 24 | 6 | 1 | 3 | 14 | 28 | 50 | −22 | 23 | |
| 11 | PC | Portland Timbers 2 | 24 | 2 | 4 | 0 | 18 | 29 | 66 | −37 | 14 |
Source: MLSNP Western Conference
Rules for classification: 1) points; 2) total wins; 3) total goal differential; 4) total goals scored; 5) fewer disciplinary points; 6) away goal differential; 7) away goals scored; 8) home goals differential; 9) home goals scored; 10) coin toss (2 clubs tied) or drawing of lots (≥3 clubs tied)
Rules for classification: 1) points; 2) total wins; 3) total goal differential; 4) total goals scored; 5) fewer disciplinary points; 6) away goal differential; 7) away goals scored; 8) home goals differential; 9) home goals scored; 10) coin toss (2 clubs tied) or drawing of lots (≥3 clubs tied)