Talk:SCN8A

Untitled

I am planning to reorganize and expand information as follows:

Function: Domains, gene expression

Clinical significance: Expand upon epilepsy and possibly introduce information about other channelopathies such as encephalitis and MS

History: Relocate channel discoveries here

Please let me know if you have suggestions for other edits. Nina.juansing (talk) 23:06, 30 October 2016 (UTC)

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Nina.juansing.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 08:30, 17 January 2022 (UTC)

Peer review

Greetings, The article was concise and easily understandable with few to no corrections that I could make. The layout was fine and as a general idea if you want to add more to this page, maybe you could add a specific relationship between Nav1.6 and another theme such as a memory that is currently being studied. Specifically, maybe adding a section on an interesting line of study where nav1.6 is being manipulated to understand a certain biological process. I was unsure as to what you were trying to say here so I did not change the sentence. I just wanted to highlight that maybe the sentence could be reworked to be read more clearly. It is a tad confusing to go from the anatomy of the neuron to the types of neurons where nav1.6 is primarily found and then back to mentioning the anatomy of neurons.Pizzaman1995 (talk) 22:20, 15 November 2016 (UTC)

"Nav1.6 is expressed primarily in the nodes of Ranvier in myelinated axons but is also highly concentrated at the distal end of the axon hillock, cerebellar granule cells and Purkinje neurons and to a lower extent in non-myelinated axons and dendrites"

Hi, Firstly, great edits. Everything was clear, concise and added to expand the depth of knowledge regarding the protein. First, I noticed that in the function section, superscript citation 8 was listed twice. I can tell that you completely reworked the page moving things into a clinical significance section and rewriting the paragraph for clarity was a great idea! There is nothing specific from reading this that I think you can add other than possibly more material if any exists. The function section does a great job at explaining the protein's role as a sodium ion transporter and comparing it to other transporters was a good idea. I'm unsure if you've added 10 references/citations because I only see a total of 11 and I doubt the previous page only had one article. Perhaps the clinical significance section can be expanded to add more mutation like effects on the transporter. Additionally, maybe presence in nonhuman organisms could be interesting as well. Seeing whether the exact protein is found in other organisms or variations that act similar could add a great deal to the page. Itsimchi (talk) 09:41, 22 November 2016 (UTC)