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Error
editThe original paper did not call for -30C for the reaction. They actually note that it should be done cold, but ice-water is used: hardly -30C! The book 'The Case of the Frozen Addicts' mentions -30C which is where the error crept in. The original work is in Danish patent 60,592 for people who wish to check. Kidston heated the resulting solution to remove the solvent & unreacted anhydride. THIS is what lead to the dehydration. The cited paper notes that the product loses analgesic activity when stored at 25-40C over a period of months. — Preceding unsigned comment added by 86.30.243.179 (talk) 18:49, 17 March 2012 (UTC)
Reversed ester
editAbout the phrase "Chemically, it is a reversed ester of pethidine which has about 70% of the potency of morphine". I'm not a chemist, but I have read that the term "reversed ester" does not belong to chemical terminology. So I would suggest to change that with the appropriate one.(ryochan) — Preceding unsigned comment added by Ryochan (talk • contribs) 10:08, 28 December 2018 (UTC)
- As a practicing chemist, I hear and use the term "reversed ester" (and similarly, "reversed amide") regularly. I don't know of any equivalent term that would be more appropriate. -- Ed (Edgar181) 13:08, 28 December 2018 (UTC)