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A fact from Complex vertebral malformation appeared on Wikipedia's Main Page in the Did you know column on 15 September 2011 (check views). The text of the entry was as follows:
Did you know... that the exceptional Holstein sire Carlin M Ivanhoe Bell passed on the genes for both good milk production and complex vertebral malformation, a lethal genetic disorder?
@Montanabw: I've now learned about ECVM, and can say, not much besides the involvement of vertebral malformations. Most obviously, even severe ECVM is not fatal, and even the least severe bovine CVM is. ECVM causes irregularities mostly around C6 and C7, sometimes the first ribs and thoracic spine. Even severely affected animals are viable and can have normal lifespans if not put down for QOL reasons or after suffering an accident. A typical CVM affected horse is able to work, but has intermittent-persistent issues with balance, pain behaviours, physical asymmetry, proprioception, unexplained by other causes and unresponsive to treatment and rehabilitative training. The inheritability is more complicated. Bovine CVM is a simple Mendelian recessive with wider influence, causing abnormal neck and limb length, carpal contracture, and scoliosis of the entire spine. A typical CVM individual ends up as a failure to conceive or early stage miscarriage. Among those that develop more, most are stillborn with plainly visible, incompatible-with-life malformations, usually short and crooked forelegs, short neck. Live birth is possible but exceedingly rare, and euthanasia is the only option. Poster on live birth CVM case with radiographs, necropsy photo. --Pitke (talk) 13:29, 20 April 2024 (UTC)Reply
