Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.[3][4]

TPTE
Identifiers
AliasesTPTE, CT44, PTEN2, transmembrane phosphatase with tensin homology
External IDsOMIM: 604336; GeneCards: TPTE; OMA:TPTE - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_199261
NM_001290224
NM_199259
NM_199260

n/a

RefSeq (protein)

NP_001277153
NP_954868
NP_954869
NP_954870

n/a

Location (UCSC)Chr 21: 10.52 – 10.61 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

edit

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[4] TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipid phosphatase;[5] TPTE itself is predicted to lack phosphatase activity.[6] TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000274391Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893.
  4. ^ a b "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".
  5. ^ Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336.
  6. ^ Chen, Mark J.; Dixon, Jack E.; Manning, Gerard (2017-04-11). "Genomics and evolution of protein phosphatases". Sci. Signal. 10 (474): eaag1796. doi:10.1126/scisignal.aag1796. ISSN 1945-0877. PMID 28400531. S2CID 41041971.

Further reading

edit