Simkin is a given name and a surname. As a surname in Slavic countries it's used for males, while the feminine counterpart is Simkina. It may refer to
- Given name
- Simkin de Pio (born 1976), Filipino painter
- Surname
- Daniil Simkin (born 1987), Russian ballet dancer
- Darren Simkin (born 1970), English football player
- Jim Simkin (1919–1984), Canadian-American psychotherapist
- John Simkin (1883–1967) Anglican Bishop in New Zealand
- Dr J. L. Simkin (1833–1905) British biochemist
- Richard Simkin (1850–1926), British artist and illustrator of military uniforms
- Toby Simkin (born 1964), theatrical producer
- William E. Simkin (1907–1992), American labor mediator and private arbitrator
- Other
- Simkin (character), in "Dark Sword"