Serkis is a surname. Notable people with the name include:
- Andy Serkis (born 1964), British film actor, director and author
- Louis Ashbourne Serkis (born 2004), British actor
- Ruby Ashbourne Serkis (born 1998), British actress
- Aïbeg and Serkis, also Aibeg and Sergis or Aïbäg and Särgis, two ambassadors sent by the Mongol ruler Baichu to Pope Innocent IV in 1247–1248