SYT11

Synaptotagmin-11 is a protein that in humans is encoded by the SYT11 gene.

SYT11
Identifiers
Aliases	SYT11, SYT12, sytXI, synaptotagmin 11
External IDs	OMIM: 608741; MGI: 1859547; HomoloGene: 23120; GeneCards: SYT11; OMA:SYT11 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 155,859,567 bp End 155,885,199 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 38.96 cM Start 88,652,007 bp End 88,682,471 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone external globus pallidus lateral nuclear group of thalamus inferior ganglion of vagus nerve postcentral gyrus pars reticulata prefrontal cortex Brodmann area 46 pars compacta ventral tegmental area Top expressed in motor neuron Rostral migratory stream anterior horn of spinal cord substantia nigra dorsomedial hypothalamic nucleus ventral tegmental area pontine nuclei subiculum medial dorsal nucleus dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding calcium ion binding syntaxin binding protein binding metal ion binding translation initiation factor binding ubiquitin protein ligase binding SNARE binding protein homodimerization activity beta-tubulin binding calcium-dependent phospholipid binding phosphatidylserine binding Cellular component integral component of membrane cell junction synapse integral component of plasma membrane synaptic vesicle membrane membrane cytoplasmic vesicle vesicle phagocytic cup presynaptic active zone membrane inhibitory synapse synaptic vesicle presynapse dendritic spine lysosome cytoplasm recycling endosome postsynaptic density plasma membrane cell body axon early phagosome excitatory synapse neuron projection terminal bouton phagocytic vesicle perinuclear region of cytoplasm integral component of synaptic vesicle membrane Schaffer collateral - CA1 synapse postsynapse integral component of presynaptic active zone membrane exocytic vesicle Biological process negative regulation of neurotransmitter secretion regulation of phagosome maturation regulation of defense response to bacterium calcium ion-regulated exocytosis of neurotransmitter negative regulation of synaptic vesicle endocytosis negative regulation of membrane invagination vesicle fusion protein homotetramerization negative regulation of clathrin-dependent endocytosis negative regulation of phagocytosis positive regulation of protein localization to phagocytic vesicle plasma membrane repair response to wounding negative regulation of clathrin-coated pit assembly calcium ion regulated lysosome exocytosis regulation of calcium ion-dependent exocytosis regulation of dopamine secretion vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23208 229521 Ensembl ENSG00000132718 ENSMUSG00000068923 UniProt Q9BT88 Q9R0N3 RefSeq (mRNA) NM_152280 NM_018804 RefSeq (protein) NP_689493 NP_061274 Location (UCSC) Chr 1: 155.86 – 155.89 Mb Chr 3: 88.65 – 88.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SYT11 has been shown to interact with Parkin (ligase).

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Huynh DP, Scoles DR, Nguyen D, Pulst SM (October 2003). "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI". Human Molecular Genetics. 12 (20): 2587–97. doi:10.1093/hmg/ddg269. PMID 12925569.
• Glass AS, Huynh DP, Franck T, Woitalla D, Müller T, Pulst SM, Berg D, Krüger R, Riess O (2004). "Screening for mutations in synaptotagmin XI in Parkinson's disease". Focus on Extrapyramidal Dysfunction. Journal of Neural Transmission. Supplementa. Vol. 68. pp. 21–8. doi:10.1007/978-3-7091-0579-5_3. ISBN 978-3-211-21114-4. PMID 15354386. {{cite book}}: |journal= ignored (help)
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Inoue S, Imamura A, Okazaki Y, Yokota H, Arai M, Hayashi N, Furukawa A, Itokawa M, Oishi M (April 2007). "Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia". American Journal of Medical Genetics Part B. 144B (3): 332–40. doi:10.1002/ajmg.b.30465. PMID 17192956. S2CID 34046711.