SLU-PP-332

SLU-PP-332
Names
	Preferred IUPAC name 4-hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide
	Other names SLU-PP-332
Identifiers
CAS Number	303760-60-3;
3D model (JSmol)	Interactive image;
ChemSpider	673181;
PubChem CID	5404083;
	InChI InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)/b19-12- Key: RNZIMBFHRXYRLL-UNOMPAQXSA-N;
	SMILES C1=CC=C2C=C(C=CC2=C1)/C=N\NC(=O)C3=CC=C(C=C3)O;
Properties
Chemical formula	C18H14N2O2
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

SLU-PP-332 is a compound which is a potent but non-selective estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC₅₀ of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting a possible role for compounds from this class as medications for the treatment of obesity.^[1]^[2]^[3]^[4]^[5]

References

^ US 8680150, Zhi L, Hudson AR, Van Oeveren CA, Roach SL, Pickens JC, Shen Y, Cuervo C, Valdez LJ, Basinger J, Grant VH, "Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors.", issued 25 March 2014, assigned to Ligand Pharmaceuticals Inc.
^ Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, et al. (April 2023). "Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity". ACS Chemical Biology. 18 (4): 756–771. doi:10.1021/acschembio.2c00720. PMC 11584170. PMID 36988910. S2CID 257803892.
^ Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, et al. (September 2023). "A Synthetic ERR Agonist Alleviates Metabolic Syndrome". The Journal of Pharmacology and Experimental Therapeutics. 388 (2): 232–240. doi:10.1124/jpet.123.001733. PMC 10801787. PMID 37739806. S2CID 262147173.
^ Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, et al. (September 2023). "Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney". The American Journal of Pathology. 193 (12): 1969–1987. doi:10.1016/j.ajpath.2023.07.008. PMC 10734281. PMID 37717940. S2CID 262046570.
^ "Exercise-mimicking drug sheds weight, boosts muscle activity in mice". news.ufl.edu. Retrieved 2023-10-05.