SAM domain, SH3 domain and nuclear localization signals 1

SAM domain-containing protein SAMSN-1 is a protein that in humans is encoded by the SAMSN1 gene.

SAMSN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KEA
Identifiers
Aliases	SAMSN1, HACS1, NASH1, SASH2, SH3D6B, SLy2, SAM domain, SH3 domain and nuclear localization signals 1
External IDs	OMIM: 607978; MGI: 1914992; HomoloGene: 11148; GeneCards: SAMSN1; OMA:SAMSN1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q11.2 Start 14,485,228 bp End 14,658,821 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C3.1 Start 75,655,681 bp End 75,819,169 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow appendix bone marrow cells monocyte right lung blood spleen lymph node epithelium of nasopharynx trabecular bone Top expressed in granulocyte lumbar spinal ganglion mesenteric lymph nodes neural layer of retina spleen bone marrow blood thymus tibiofemoral joint fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function phosphotyrosine residue binding RNA binding Cellular component cytoplasm ruffle cytosol cell projection nucleus plasma membrane Biological process negative regulation of B cell activation negative regulation of peptidyl-tyrosine phosphorylation negative regulation of adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64092 67742 Ensembl ENSG00000155307 ENSMUSG00000022876 UniProt Q9NSI8 P57725 RefSeq (mRNA) NM_001256370 NM_001286523 NM_022136 NM_023380 RefSeq (protein) NP_001243299 NP_001273452 NP_071419 NP_075869 Location (UCSC) Chr 21: 14.49 – 14.66 Mb Chr 16: 75.66 – 75.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).

See also

• SASH1

Further reading

• Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, Trieu Y, Bali M, McGlade CJ, Claudio JO, Stewart AK (2004). "The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades". J. Exp. Med. 200 (6): 737–47. doi:10.1084/jem.20031816. PMC 2211965. PMID 15381729.
• Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T (2008). "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer". Genes Chromosomes Cancer. 47 (9): 810–8. doi:10.1002/gcc.20582. PMID 18523997. S2CID 39369334.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Brandt S, Ellwanger K, Beuter-Gunia C, Schuster M, Hausser A, Schmitz I, Beer-Hammer S (2010). "SLy2 targets the nuclear SAP30/HDAC1 complex". Int. J. Biochem. Cell Biol. 42 (9): 1472–81. doi:10.1016/j.biocel.2010.05.004. PMID 20478393.
• von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S (2011). "Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading". J. Biol. Chem. 286 (15): 13489–501. doi:10.1074/jbc.M110.155184. PMC 3075695. PMID 21296879.
• Yan Y, Zhang L, Xu T, Zhou J, Qin R, Chen C, Zou Y, Fu D, Hu G, Chen J, Lu Y (2013). "SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme". PLOS ONE. 8 (11): e81905. Bibcode:2013PLoSO...881905Y. doi:10.1371/journal.pone.0081905. PMC 3838348. PMID 24278465.
• Noll JE, Hewett DR, Williams SA, Vandyke K, Kok C, To LB, Zannettino AC (2014). "SAMSN1 is a tumor suppressor gene in multiple myeloma". Neoplasia. 16 (7): 572–85. doi:10.1016/j.neo.2014.07.002. PMC 4198825. PMID 25117979.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.