RacCS203 is a bat-derived strain of severe acute respiratory syndrome–related coronavirus collected in acuminate horseshoe bats from sites in Thailand and sequenced by Lin-Fa Wang's team. It has 91.5% sequence similarity to SARS-CoV-2 and is most related to the RmYN02 strain. Its spike protein is closely related to RmYN02's spike, both highly divergent from SARS-CoV-2's spike.[1][2]
| RacCS203 | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Nidovirales |
| Family: | Coronaviridae |
| Genus: | Betacoronavirus |
| Subgenus: | Sarbecovirus |
| Species: | |
| Strain: | RacCS203
|
Phylogenetics
editPhylogenetic tree
editA phylogenetic tree based on whole-genome sequences of SARS-CoV-2 and related coronaviruses is:[3][4]
| SARS‑CoV‑2 related coronavirus |
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SARS-CoV-1, 79% to SARS-CoV-2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genome comparison
edit| SARS-CoV-2 compared to other SARSr-CoV (by nucleotide %)[13] | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Full-length genome | ORF1ab | S | RBM | ORF3a | E | M | ORF6 | ORF7a | ORF7b | ORF8 | N | ORF10 |
| RaTG13 | 96.10% | 96.50% | 92.30% | 86.30% | 96.30% | 99.60% | 95.50% | 98.40% | 95.60% | 99.20% | 97.00% | 96.90% | 99.20% |
| RmYN02 | 93.60% | 97.10% | 72.50% | 61.90% | 96.40% | 98.70% | 94.80% | 96.80% | 96.20% | 91.00% | 48.70% | 97.30% | 99.20% |
| RacCS203 | 91.50% | 94.30% | 71.30% | 61.60% | 91.90% | 99.10% | 94.60% | 96.20% | 92.40% | 93.90% | 91.60% | 93.20% | 99.20% |
| GD/1/2019 | 90.20% | 90.20% | 83.70% | 86.90% | 93.20% | 99.10% | 93.30% | 95.70% | 93.40% | 91.70% | 92.10% | 96.20% | 99.20% |
| SL-ZC45 | 87.70% | 89.00% | 75.50% | 62.50% | 87.80% | 98.70% | 93.40% | 94.60% | 88.80% | 94.70% | 88.50% | 91.10% | 99.20% |
| SL-ZXC21 | 87.50% | 88.70% | 74.90% | 61.60% | 88.90% | 98.70% | 93.40% | 94.60% | 89.10% | 95.50% | 88.50% | 91.20% | 99.20% |
| GX-P4L | 85.40% | 84.80% | 83.60% | 80.00% | 86.80% | 97.40% | 91.30% | 90.90% | 86.60% | 83.50% | 81.30% | 91.00% | 88.90% |
| GX-P5L | 85.20% | 84.60% | 83.30% | 79.90% | 87.00% | 97.40% | 91.30% | 90.90% | 86.40% | 83.50% | 80.70% | 91.00% | 94.00% |
| SARS-CoV | 79.30% | 79.70% | 72.30% | 71.90% | 75.30% | 93.50% | 85.50% | 75.50% | 82.10% | 83.80% | 45.80% | 88.20% | 93.20% |
| Rc-o319 | 79.20% | 79.80% | 72.20% | 70.10% | 83.30% | 97.40% | 86.60% | 86.60% | 78.40% | 77.30% | 52.30% | 88.30% | 94.90% |
| SARS-CoV-2 compared to other SARSr-CoV (by amino acid %)[13] | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Full-length genome | ORF1ab | S | RBM | ORF3a | E | M | ORF6 | ORF7a | ORF7b | ORF8 | N | ORF10 |
| RaTG13 | 98.50% | 97.30% | 90.10% | 97.80% | 100.00% | 99.60% | 100.00% | 97.50% | 97.70% | 95.00% | 99.10% | 97.40% | |
| RmYN02 | 98.80% | 72.40% | 63.20% | 96.70% | 100.00% | 98.70% | 96.70% | 95.90% | 83.70% | 28.20% | 98.60% | 97.40% | |
| RacCS203 | 97.30% | 72.30% | 63.70% | 97.50% | 100.00% | 99.10% | 98.40% | 95.90% | 93.00% | 94.20% | 95.70% | - | |
| GD/1/2019 | 96.70% | 90.00% | 96.90% | 97.10% | 100.00% | 98.70% | 96.70% | 97.50% | 95.40% | 95.00% | 97.90% | 97.40% | |
| SL-ZC45 | 95.60% | 80.20% | 65.90% | 90.90% | 100.00% | 98.70% | 93.40% | 87.60% | 93.00% | 94.20% | 94.30% | 97.40% | |
| SL-ZXC21 | 95.20% | 79.70% | 65.90% | 92.00% | 100.00% | 98.70% | 93.40% | 88.40% | 93.00% | 94.20% | 94.30% | - | |
| GX-P4L | 92.50% | 92.30% | 86.60% | 89.50% | 100.00% | 98.20% | 95.10% | 88.40% | - | 87.60% | 93.60% | 73.70% | |
| GX-P5L | 92.50% | 92.40% | 86.60% | 89.80% | 100.00% | 98.20% | 95.10% | 88.40% | 72.10% | 87.60% | 93.80% | 84.20% | |
| SARS-CoV | 86.10% | 75.80% | 73.10% | 72.40% | 94.70% | 90.50% | 67.20% | 85.30% | 81.40% | - | 90.50% | 81.60% | |
| Rc-o319 | 87.60% | 76.20% | 73.50% | 87.00% | 98.70% | 91.00% | 83.60% | 73.80% | 69.80% | 26.80% | 89.50% | 86.80% | |
See also
editReferences
edit- ^ Wacharapluesadee, S; Tan, CW; Maneeorn, P; Duengkae, P; Zhu, F; Joyjinda, Y; Kaewpom, T; Chia, WN; Ampoot, W; Lim, BL; Worachotsueptrakun, K; Chen, VC; Sirichan, N; Ruchisrisarod, C; Rodpan, A; Noradechanon, K; Phaichana, T; Jantarat, N; Thongnumchaima, B; Tu, C; Crameri, G; Stokes, MM; Hemachudha, T; Wang, LF (9 February 2021). "Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia". Nature Communications. 12 (1): 972. Bibcode:2021NatCo..12..972W. doi:10.1038/s41467-021-21240-1. PMC 7873279. PMID 33563978.
- ^ "Coronavirus: Bat scientists find new evidence". BBC News. 10 February 2021.
- ^ a b Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, et al. (August 2021). "Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses". Cell. 184 (17): 4380–4391.e14. doi:10.1016/j.cell.2021.06.008. PMC 8188299. PMID 34147139.
- ^ a b Wacharapluesadee S, Tan CW, Maneeorn P, Duengkae P, Zhu F, Joyjinda Y, et al. (February 2021). "Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia". Nature Communications. 12 (1): 972. Bibcode:2021NatCo..12..972W. doi:10.1038/s41467-021-21240-1. PMC 7873279. PMID 33563978.
- ^ Murakami S, Kitamura T, Suzuki J, Sato R, Aoi T, Fujii M, et al. (December 2020). "Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan". Emerging Infectious Diseases. 26 (12): 3025–3029. doi:10.3201/eid2612.203386. PMC 7706965. PMID 33219796.
- ^ a b Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi:10.1016/j.cub.2020.05.023. PMC 7211627. PMID 32416074.
- ^ Lam TT, Jia N, Zhang YW, Shum MH, Jiang JF, Zhu HC, et al. (July 2020). "Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins". Nature. 583 (7815): 282–285. Bibcode:2020Natur.583..282L. doi:10.1038/s41586-020-2169-0. PMID 32218527. S2CID 214683303.
- ^ Xiao K, Zhai J, Feng Y, Zhou N, Zhang X, Zou JJ, et al. (July 2020). "Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins". Nature. 583 (7815): 286–289. Bibcode:2020Natur.583..286X. doi:10.1038/s41586-020-2313-x. PMID 32380510. S2CID 256822274.
- ^ a b Delaune D, Hul V, Karlsson EA, Hassanin A, Ou TP, Baidaliuk A, et al. (November 2021). "A novel SARS-CoV-2 related coronavirus in bats from Cambodia". Nature Communications. 12 (1): 6563. Bibcode:2021NatCo..12.6563D. doi:10.1038/s41467-021-26809-4. PMC 8578604. PMID 34753934.
- ^ Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi:10.1016/j.cub.2020.05.023. PMC 7211627. PMID 32416074.
- ^ Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270–273. Bibcode:2020Natur.579..270Z. doi:10.1038/s41586-020-2012-7. PMC 7095418. PMID 32015507.
- ^ Temmam S, Vongphayloth K, Baquero E, Munier S, Bonomi M, Regnault B, et al. (April 2022). "Bat coronaviruses related to SARS-CoV-2 and infectious for human cells". Nature. 604 (7905): 330–336. Bibcode:2022Natur.604..330T. doi:10.1038/s41586-022-04532-4. PMID 35172323. S2CID 246902858.
- ^ a b Wacharapluesadee, Supaporn; Tan, Chee Wah; Maneeorn, Patarapol; Duengkae, Prateep; Zhu, Feng; Joyjinda, Yutthana; Kaewpom, Thongchai; Chia, Wan Ni; Ampoot, Weenassarin; Lim, Beng Lee; Worachotsueptrakun, Kanthita (2021-02-09). "Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia". Nature Communications. 12 (1): 972. Bibcode:2021NatCo..12..972W. doi:10.1038/s41467-021-21240-1. ISSN 2041-1723. PMC 7873279. PMID 33563978.
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