RASAL2

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.

RASAL2
Identifiers
Aliases	RASAL2, NGAP, RAS protein activator like 2
External IDs	OMIM: 606136; MGI: 2443881; HomoloGene: 35217; GeneCards: RASAL2; OMA:RASAL2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q25.2 Start 178,094,104 bp End 178,484,147 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H1 Start 156,962,752 bp End 157,240,165 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell amniotic fluid right ventricle oral cavity middle temporal gyrus saphenous vein sural nerve Brodmann area 23 mucosa of paranasal sinus tendon of biceps brachii Top expressed in sciatic nerve utricle primary motor cortex cingulate gyrus trigeminal ganglion lateral septal nucleus piriform cortex Temporal Lobe anterior amygdaloid area prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm cytosol intrinsic component of the cytoplasmic side of the plasma membrane Biological process negative regulation of Ras protein signal transduction regulation of GTPase activity signal transduction MAPK cascade positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9462 226525 Ensembl ENSG00000075391 ENSMUSG00000070565 UniProt Q9UJF2 n/a RefSeq (mRNA) NM_004841 NM_170692 NM_177644 NM_001401202 RefSeq (protein) NP_004832 NP_733793 n/a Location (UCSC) Chr 1: 178.09 – 178.48 Mb Chr 1: 156.96 – 157.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Further reading

• Maekawa M, Nakamura S, Hattori S (1993). "Purification of a novel ras GTPase-activating protein from rat brain". J. Biol. Chem. 268 (30): 22948–52. doi:10.1016/S0021-9258(18)41618-3. PMID 8226805.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.