Proteomimetics are molecules that mimic certain protein characteristics such as shape, binding properties or enzymatic activity.[1] While conceptually linked to peptidomimetics which mimic short peptide sequences or secondary structures, proteomimetics recapitulate tertiary structures. This can involve the mimicry of entire protein domains[2] or fragments thereof.[3] Proteomimetic approaches can range from entirely abiotic scaffolds[2] to specific main chain and side chain-modifications.[4][5]
References
edit- ^ Horne WS, Grossmann TN (April 2020). "Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns". Nat. Chem. 12 (4): 331–337. Bibcode:2020NatCh..12..331H. doi:10.1038/s41557-020-0420-9. PMC 7739441. PMID 32029906.
- ^ a b De S, Chi B, Granier T, Qi T, Maurizot V, Huc I (January 2018). "Designing cooperatively folded abiotic uni- and multimolecular helix bundles" (PDF). Nat. Chem. 10 (1): 51–57. Bibcode:2018NatCh..10...51D. doi:10.1038/nchem.2854. PMID 29256508.
- ^ Paulussen FM, Schouten GK, Moertl C, Verheul J, Hoekstra I, Koningstein GM, Hutchins GH, Alkir A, Luirink RA, Geerke DP, van Ulsen P, den Blaauwen T, Luirink J, Grossmann TN (August 2022). "Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex". J. Am. Chem. Soc. 144 (33): 15303–15313. doi:10.1021/jacs.2c06304. PMC 7739441. PMID 32029906.
- ^ Cabalteja CC, Mihalko DS, Horne WS (November 2018). "Heterogeneous-backbone foldamer mimics of a computationally designed, disulfide-rich miniprotein". ChemBioChem. 20 (4): 103–110. doi:10.1002/cbic.201800558. PMC 239472. PMID 6314896.
- ^ Pelay-Gimeno M, Bange T, Hennig S, Grossmann TN (August 2018). "In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme". Angew. Chem. Int. Ed. 57 (35): 11164–11170. doi:10.1002/anie.201804506. PMC 6120448. PMID 6120448.
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