Proline rich 5 like

Proline rich 5 like is a protein that in humans is encoded by the PRR5L gene.

PRR5L
Identifiers
Aliases	PRR5L, PROTOR2, proline rich 5 like
External IDs	OMIM: 611728; MGI: 1919696; HomoloGene: 11753; GeneCards: PRR5L; OMA:PRR5L - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p13-p12 Start 36,296,288 bp End 36,465,204 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E2 Start 101,544,630 bp End 101,713,372 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon granulocyte rectum spleen C1 segment secondary oocyte testicle corpus callosum monocyte mucosa of sigmoid colon Top expressed in hand lumbar subsegment of spinal cord molar hair follicle zygote serosa of urinary bladder primary oocyte secondary oocyte skin of hand medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase binding protein binding Cellular component TORC2 complex Biological process TORC2 signaling negative regulation of protein phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of signal transduction positive regulation of protein phosphorylation regulation of fibroblast migration cellular response to oxidative stress positive regulation of mRNA catabolic process positive regulation of intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79899 72446 Ensembl ENSG00000135362 ENSMUSG00000032841 UniProt Q6MZQ0 A2AVJ5 RefSeq (mRNA) NM_024841 NM_001160167 NM_001160168 NM_001160169 NM_001083810 NM_001110849 NM_175181 NM_001355625 RefSeq (protein) NP_001153639 NP_001153640 NP_001153641 NP_079117 NP_001077279 NP_001104319 NP_780390 NP_001342554 Location (UCSC) Chr 11: 36.3 – 36.47 Mb Chr 2: 101.54 – 101.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR (2007). "Identification of Protor as a novel Rictor-binding component of mTOR complex-2". Biochem. J. 405 (3): 513–22. doi:10.1042/BJ20070540. PMC 2267312. PMID 17461779.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.