Areas affected by the hurricane (excluding Bermuda)

The Great Hurricane of 1780, also known as the Hurricane San Calixto II, is the deadliest Atlantic hurricane on record. Over 27,500 people died when the storm passed through the Lesser Antilles in the Caribbean between October 10 and October 16. Specifics on the hurricane's track and strength are unknown since the official Atlantic hurricane database only goes back to 1851.

The hurricane struck Barbados with winds possibly exceeding 320 km/h (200 mph), before moving past Martinique, Saint Lucia, and Sint Eustatius; thousands of deaths were reported on each island. Coming in the midst of the American Revolution, the storm caused heavy losses to British and French fleets contesting for control of the area. The hurricane later passed near Puerto Rico and over the eastern portion of the Dominican Republic, which at the time was known as Santo Domingo. There, it caused heavy damage near the coastlines; it ultimately turned to the northeast before being last observed on October 20 southeast of Cape Race, Newfoundland.