A flexible-fuel vehicle (FFV) (or flex-fuel vehicle) is an alternative fuel vehicle with an internal combustion engine designed to run on more than one fuel, usually gasoline blended with either ethanol or methanol fuel, and both fuels are stored in the same common tank. The most common commercially available FFV in the world market is the ethanol flexible-fuel vehicle, with around 21 million automobiles, motorcycles and light duty trucks sold worldwide by mid 2010, and concentrated in four markets, Brazil (10.6 million), the United States (9.3 million), Canada (more than 600,000), and Europe, led by Sweden (199,000). Also a total of 183,375 flexible-fuel motorcycles were sold in Brazil in 2009. In addition to flex-fuel vehicles running with ethanol, in Europe and the US, mainly in California, there have been successful test programs with methanol flex-fuel vehicles, known as M85 flex-fuel vehicles.

Though technology exists to allow ethanol FFVs to run on any mixture of gasoline and ethanol, from pure gasoline up to 100% ethanol (E100), North American and European flex-fuel vehicles are optimized to run on a maximum blend of 15% gasoline with 85% anhydrous ethanol (called E85 fuel). This limit in the ethanol content is set to reduce ethanol emissions at low temperatures and to avoid cold starting problems during cold weather, at temperatures lower than 11 °C (52 °F). The alcohol content is reduced during the winter in regions where temperatures fall below 0 °C (32 °F) to a winter blend of E70 in the U.S. or to E75 in Sweden from November until March. Brazilian flex fuel vehicles are optimized to run on any mix of E20-E25 gasoline and up to 100% hydrous ethanol fuel (E100).