Phosphatidylethanolamine binding protein 1

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene.

PEBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BD9, 1BEH, 2L7W, 2QYQ
Identifiers
Aliases	PEBP1, HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP, HEL-S-96, Phosphatidylethanolamine binding protein 1
External IDs	OMIM: 604591; MGI: 1344408; HomoloGene: 37637; GeneCards: PEBP1; OMA:PEBP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.23 Start 118,136,124 bp End 118,145,584 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 56.88 cM Start 117,420,719 bp End 117,425,690 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla postcentral gyrus right adrenal cortex left adrenal gland left adrenal cortex internal globus pallidus superior frontal gyrus Brodmann area 9 prefrontal cortex superior vestibular nucleus Top expressed in testicle spermatid adrenal gland Mesencephalon proximal tubule spermatocyte neural tube dentate gyrus of hippocampal formation granule cell hippocampus proper lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding nucleotide binding protein kinase binding phosphatidylethanolamine binding serine-type endopeptidase inhibitor activity ATP binding enzyme binding peptidase inhibitor activity RNA binding signaling receptor binding mitogen-activated protein kinase binding Cellular component cytoplasm cytosol nucleus extracellular exosome extracellular space mitochondrion mitochondrial outer membrane Golgi apparatus synaptic vesicle cell surface soma myelin sheath axon terminus apical part of cell Biological process MAPK cascade negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of neurotransmitter levels regulation of the force of heart contraction response to oxidative stress ageing response to heat response to wounding response to toxic substance response to organonitrogen compound response to activity hippocampus development negative regulation of MAPK cascade positive regulation of cAMP-mediated signaling response to ethanol positive regulation of mitotic nuclear division sperm capacitation response to corticosterone response to cAMP response to calcium ion positive regulation of acetylcholine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5037 23980 Ensembl ENSG00000089220 ENSMUSG00000032959 UniProt P30086 P70296 RefSeq (mRNA) NM_002567 NM_018858 RefSeq (protein) NP_002558 NP_061346 Location (UCSC) Chr 12: 118.14 – 118.15 Mb Chr 5: 117.42 – 117.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Phosphatidylethanolamine binding protein 1 has been shown to interact with:

• C-Raf,
• MAP2K1, and
• MAPK1.

Further reading

• Schoentgen F, Jollès P (1995). "From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site". FEBS Lett. 369 (1): 22–6. doi:10.1016/0014-5793(95)00376-K. PMID 7641877. S2CID 25555428.
• Ojika K, Mitake S, Tohdoh N, Appel SH, Otsuka Y, Katada E, Matsukawa N (2000). "Hippocampal cholinergic neurostimulating peptides (HCNP)". Prog. Neurobiol. 60 (1): 37–83. doi:10.1016/S0301-0082(99)00021-0. PMID 10622376. S2CID 13466181.
• Odabaei G, Chatterjee D, Jazirehi AR, Goodglick L, Yeung K, Bonavida B (2004). Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. Advances in Cancer Research. Vol. 91. pp. 169–200. doi:10.1016/S0065-230X(04)91005-6. ISBN 9780120066919. PMID 15327891. {{cite book}}: |journal= ignored (help)
• Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Tohdoh N, Tojo S, Agui H, Ojika K (1995). "Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein". Brain Res. Mol. Brain Res. 30 (2): 381–4. doi:10.1016/0169-328X(95)00029-R. PMID 7637590.
• Seddiqi N, Bollengier F, Alliel PM, Périn JP, Bonnet F, Bucquoy S, Jollès P, Schoentgen F (1994). "Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues". J. Mol. Evol. 39 (6): 655–60. Bibcode:1994JMolE..39..655S. doi:10.1007/BF00160411. PMID 7807553. S2CID 21554565.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hori N, Chae KS, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K (1994). "A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein". Gene. 140 (2): 293–4. doi:10.1016/0378-1119(94)90562-2. PMID 8144042.
• Moore C, Perry AC, Love S, Hall L (1996). "Sequence analysis and immunolocalisation of phosphatidylethanolamine binding protein (PBP) in human brain tissue". Brain Res. Mol. Brain Res. 37 (1–2): 74–8. doi:10.1016/0169-328X(95)00285-Z. PMID 8738137.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Banfield MJ, Barker JJ, Perry AC, Brady RL (1998). "Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction". Structure. 6 (10): 1245–54. doi:10.1016/S0969-2126(98)00125-7. PMID 9782050.
• Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W (1999). "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP" (PDF). Nature. 401 (6749): 173–7. Bibcode:1999Natur.401..173Y. doi:10.1038/43686. PMID 10490027. S2CID 4379551.
• Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. PMC 85596. PMID 10757792.
• Hengst U, Albrecht H, Hess D, Monard D (2001). "The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors". J. Biol. Chem. 276 (1): 535–40. doi:10.1074/jbc.M002524200. PMID 11034991.
• Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904.
• Maki M, Matsukawa N, Yuasa H, Otsuka Y, Yamamoto T, Akatsu H, Okamoto T, Ueda R, Ojika K (2002). "Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease". J. Neuropathol. Exp. Neurol. 61 (2): 176–85. doi:10.1093/jnen/61.2.176. PMID 11853019.
• Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.