PIK3R4

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.

PIK3R4
Identifiers
Aliases	PIK3R4, VPS15, p150, phosphoinositide-3-kinase regulatory subunit 4
External IDs	OMIM: 602610; MGI: 1922919; HomoloGene: 24678; GeneCards: PIK3R4; OMA:PIK3R4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.1 Start 130,678,934 bp End 130,746,829 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F1|9 56.79 cM Start 105,520,177 bp End 105,564,856 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gonad anterior pituitary epithelium of colon right lobe of thyroid gland Brodmann area 9 epithelium of nasopharynx ventricular zone mucosa of transverse colon left lobe of thyroid gland Top expressed in primary oocyte secondary oocyte zygote Epithelium of choroid plexus otic vesicle motor neuron medullary collecting duct iris facial motor nucleus tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding ATP binding 1-phosphatidylinositol-3-kinase activity Cellular component cytosol endosome late endosome phagocytic vesicle membrane membrane phosphatidylinositol 3-kinase complex, class III nuclear pore autophagosome phosphatidylinositol 3-kinase complex, class III, type I axoneme nucleus-vacuole junction cytoplasmic vesicle phosphatidylinositol 3-kinase complex, class III, type II microtubule cytoskeleton intracellular membrane-bounded organelle Biological process cellular response to glucose starvation regulation of cytokinesis phosphorylation late endosome to vacuole transport autophagy of peroxisome receptor catabolic process positive regulation of phosphatidylinositol 3-kinase activity protein phosphorylation phosphatidylinositol biosynthetic process protein targeting to vacuole toll-like receptor 9 signaling pathway macroautophagy phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30849 75669 Ensembl ENSG00000196455 ENSMUSG00000032571 UniProt Q99570 Q8VD65 RefSeq (mRNA) NM_014602 NM_001081309 NM_029380 RefSeq (protein) NP_055417 NP_001074778 Location (UCSC) Chr 3: 130.68 – 130.75 Mb Chr 9: 105.52 – 105.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Askham JM, Vaughan KT, Goodson HV, Morrison EE (2002). "Evidence That an Interaction between EB1 and p150Glued Is Required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMC 129971. PMID 12388762.
• Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731. S2CID 9951653.
• Matsunaga K, Saitoh T, Tabata K, et al. (2009). "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages". Nat. Cell Biol. 11 (4): 385–96. doi:10.1038/ncb1846. PMID 19270696. S2CID 205286778.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takeshita F, Gursel I, Ishii KJ, et al. (2004). "Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9". Semin. Immunol. 16 (1): 17–22. doi:10.1016/j.smim.2003.10.009. PMID 14751759.
• Ligon LA, Shelly SS, Tokito M, Holzbaur EL (2003). "The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization". Mol. Biol. Cell. 14 (4): 1405–17. doi:10.1091/mbc.E02-03-0155. PMC 153110. PMID 12686597.
• Yan Y, Flinn RJ, Wu H, et al. (2009). "hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells". Biochem. J. 417 (3): 747–55. doi:10.1042/BJ20081865. PMC 2652830. PMID 18957027.