Oscillations are an important type of cell signaling characterized by the periodic change of the system in time.[1] Oscillations can take place in a biological system in a multitude of ways. Positive feedback loops, on their own or in combination with negative feedback are a common feature of oscillating biological systems.[2]
Examples
editGenetic oscillation
editOne of the most common forms of biological oscillation is genetic oscillation, which can take place when a transcription factor binds and represses its own promoter. This type of regulatory system is able to successfully describe the NFkB-IkB and p53-Mdm52 biological oscillating systems.[1]
Relaxation oscillations
editRelaxation oscillation takes place in the context of a bi-stable system. It is characterized by the periodic switching between two stable states.[2]