Organ donation is when a person gives their organs after they die to someone in need of new organs. Transplantation is the process of transplanting the organs donated into another person. This process extends the life expectancy of a person suffering from organ failure. The number of patients requiring organ transplants outweighs the number of donor organs available.[1]
History of organ transplantation
editAustralia's first organ transplants were corneal transplants in the early 1940s. Following in chronological order are monumental first in Australia's organ transplantation history.[2]
- Early 1940s Australia began corneal transplants in Sydney and Melbourne
- 1965 Australia's first successful (living) kidney transplant
- 1984 Australia's first successful heart transplant
- 1985 Australia's first successful liver transplant
- 1985 Australia's first successful kidney transplant from a deceased donor
- 1986 The Brisbane Technique for splitting livers to benefit three recipients initiated
- 1986 Australia's first successful heart/lung transplant
- 1987 Australia's first successful kidney/pancreas transplant
- 1987 First segmental liver transplant (for children) (Australia)
- 1989 First successful living liver transplant (Australia)
- 1990 Australia's first successful single lung transplant
- 2002 First single segment liver transplant on a baby (24 days old) (Australia)
- 2003 Australia's first triple transplant (heart, lung, liver)
- 2006 World's first kidney/liver/pancreas transplant (Australia)[2]
- 2012 Australia's first pediatric intestinal transplant (liver), (small bowel), (duodenum), (pancreas)
The following table (Table 1.1) shows the global transplantation milestones in chronological order.
Table 1.1. Global transplant milestones
edit| Year | Milestone | Location |
|---|---|---|
| 1823 | First skin auto graft transplantation of skin tissue from one location on an individual to another location | Germany |
| 1905 | First human to human corneal transplant. This was also the first successful human to human transplant of any kind | Moravia (now Czech Republic) |
| 1908 | First skin allograft-transplantation of skin from a donor to a recipient | Switzerland |
| Early 1940s | Australia begins corneal transplants | Sydney and Melbourne |
| 1954 | First living related kidney transplant (identical twins) | US |
| 1955 | First heart valve allograft into descending aorta | Canada |
| 1962 | First kidney transplant from a deceased donor | US |
| 1965 | Australia's first successful (living) kidney transplant | Queen Elizabeth hospital. South Australia |
| 1967 | First successful liver transplant | US |
| 1967 | First heart transplant | South Africa |
| 1968 | First pancreas transplant | US |
| 1979 | Living related pancreas (mother to child) | US |
| 1981 | First heart/lung transplant | US |
| 1983 | First successful lung transplant | Canada |
| 1983 | Ciclosporin approved for commercial use in the US. A revolutionary anti-rejection drug, it heralded a new era for kidney, liver and heart transplantation | US |
| 1984 | First heart-liver transplant | US |
| 1984 | Australia's first successful heart transplant | St. Vincents hospital, NSW Australia |
| 1985 | Australia's first successful liver transplant | Princess Alexandra hospital, Brisbane Australia |
| 1985 | Australia's first successful kidney transplant from a deceased donor | Queen Elizabeth hospital, Adelaide Australia |
| 1986 | First successful double lung transplant | Canada |
| 1986 | The 'Brisbane Technique' for splitting livers to benefit three recipients initiated | Princess Alexandra hospital, Brisbane Australia |
| 1986 | Australia's first successful heart/lung transplant | St Vincent's hospital, NSW Australia |
| 1987 | Australia's first successful kidney/pancreas transplant | Westmead hospital, NSW Australia |
| 1987 | First segmental liver transplant (for children) | Princess Alexandra hospital QLD Australia |
| 1988 | First successful intestinal transplant | UK |
| 1988 | First successful liver-bowel transplant | UK |
| 1988 | First two in one liver transplant (one liver split for two recipients) | France |
| 1989 | First successful living liver transplant | Princess Alexandra hospital QLD Australia |
| 1989 | First combination heart, liver and kidney transplant | US |
| 1990 | First living related lung transplant | US |
| 1990 | Australia's first successful single lung transplant | St. Vincent's hospital NSW Australia |
| 1992 | Xenotransplant (pig liver to human) | US |
| 1992 | Xenotransplant (baboon's liver to human) | US |
| 1995 | World's first laparoscopic live donor nephrectomy in which a patient's kidney is removed through a 5–6 cm incision | US |
| 1995 | Transplantation of all abdominal organs | US |
| 1998 | First successful human hand transplant (later removed) | France |
| 2002 | First single segment liver transplant on a baby (24 days) | Princess Alexandra hospital, QLD Australia |
| 2003 | Australia's first triple transplant (heart, lung, liver) | Princess Alexandra hospital, QLD Australia |
| 2005 | First successful partial face transplant | France |
| 2005 | First living donor islet transplant | Japan |
| 2006 | World's first kidney/liver/pancreas transplant | Royal Prince Alfred hospital NSW Australia |
| 2009 | Paediatric transplant for small bowel, liver, pancreas and two kidneys | US |
Table 1.1 Source: Australian Government Tissue Donation and Transplantation Authority. http://www.donatelife.gov.au
Donor types
editThere are two types of donors; living donors and deceased donors.
Living donors
editIn Australia the most common living donations not including blood donations are kidneys and bone marrow. The tissues and organs that are able to be donated by a living donor are:[3]
- Bone marrow
- Kidney
- Part of the liver
- Lung (this requires two living donors. One donates a lobe from their left lung and the other donates a lobe from their right lung)
- Part of the intestine
- Part of the pancreas[3]
Eligibility for donation
editThe minimum age for living donation is 18 years of age. A person may be eligible to be a donor if they are free from HIV, cancer, systemic infection, sickle cell anaemia, Creutzfeldt–Jakob disease and they are not a previous IV drug user.[4]
Motives for living donation
editDonation to a family member is a common scenario. The reasons for a family member to want to be a living donor to their relatives are; a desire to help, self benefit (from loved ones improved health), a feeling of moral duty, pressure identification with the recipient, increased self-esteem from doing a good deed. It is the health professional's role to understand the difficulty of these situations involving relationships of loved friends or relatives and they are to determine whether or not the offer of donation is genuine or the living donor feels pressured into donating because of the seriousness of their loved ones organ failure. However most donations result in a positive psychological benefit to both the donor and recipient.[3]
If a donor is wanting to donate to someone who is not a relative or friend they are intensively psychologically tested to determine their motives and suitability for donation as there can occasionally be harmful motives such as attention seeking or mental illness.[3]
Deceased donors (non-heart beating donors)
editDeceased donors have been declared dead and are maintained in ICU on ventilators so tissue oxygenation continues until the procedure of organ retrieval and cold preservation.[5]
Deceased donors are divided into two sub-classes.[5]
- Donation after brain death. A person is declared brain dead if there is complete loss of all brain function
- Donation after cardiac death. A person is declared cardiac dead if there is complete loss of all cardiac function[4]
Both types of deceased donors have complete and irreversible damage and returning to life is impossible. Thorough testing is carried out prior to confirming a person brain dead or cardiac dead.[4]
One deceased donor is able to save up to ten lives by donating the following:
- Organs: Kidneys, pancreas, liver, lungs, heart and intestines
- Tissues: Bones, skin, heart valves, veins and corneas[6]
Whole body donation
editAfter death some people choose to donate their bodies to science. These bodies are used in many teaching facilities and aid in teaching anatomy, surgical techniques or research. Whole body donation involves the deceased person contacting the university or teaching institution prior to death to obtain consent and cover the legalities involved. After death it is up to the family of the deceased to contact the chosen facility and arrange donation.[1]
Opt in versus opt out
editCurrently Australia's organ donation system is 'opt-in'. This means a person had to give consent (opt-in) to be a donor prior to their death, or their family can make the decision for them if they are considered a viable donor.[7] The 'opt-out' system is used in several countries around the world. For this system everyone is placed on the donor list and must 'opt-out' if they do not wish to donate their organs. Whether Australia changes to the 'opt-out' system is constantly coming into question. In a discussion paper compiled in 2011 it was stated 35% of family members of a potential donor would refuse donation if they were unsure of the family members intentions on donating. However, if an 'opt-out' system was put into place and the potential donor did not opt-out prior to death, it was estimated only 20% of families would refuse donation.[8]
A study carried out in 2002 investigated donor rates of countries with 'opt-in' and 'opt-out' systems. The countries chosen for the study were ones that had relatively similar backgrounds and health systems. After the donation rates were calculated to match the mortality rates it concluded the difference in donor rates between the two systems were marginal. The results as follows (Table 1.2).[9]
Table 1.2. Three year mean organ donation and mortality rates for 10 European countries.
editReference:[9]
| Country | Three year mean organ donation rates* (per million inhabitants) | Three year mean mortality rates† for organ donation (per million inhabitants) |
|---|---|---|
| Spain | 33.8 | 309 |
| Austria | 23.5 | 298 |
| Belgium | 23.0 | 343 |
| France | 18.3 | 330 |
| Italy | 16.8 | 246 |
| UK | 13.2 | 243 |
| Netherlands (I) | 13.0 | 187 |
| Germany (I) | 12.6 | 240 |
| Switzerland | 12.5 | 195 |
| Sweden | 11.3 | 240 |
- *The rates shown comply with the definition of the council of Europe: "if at least one solid organ has been retrieved for the purpose of organ donation"
- †Mortality rates for CVA and (traffic) accidents 0–65 years
- (I) indicates country has an 'opt-in' system
There are many pros and cons for each of the two systems, making it a controversial topic, and as seen above some studies can be contradicting. Ultimately it is the family of the deceased who will make the final decision on organ donation.[10] Only 57% of Australians know the wishes of their family members in regards to organ donation, which has a large impact on families giving consent for organ donation. Donation cannot go ahead without families consent even if the person is on the donor register.[11]
Donation in religion
editIn most cases religions support organ donation. However, there are a few aspects of each religion that can make the logistics of organ donation difficult.
Islam
editMost organ donations in predominately Muslim countries are live donations, for example in Iran in 2006 only 13% of renal transplants were from deceased donation. In Islam, violating the human body whether living or dead is forbidden, this includes organ donation. However, saving a life is ranked extremely highly in the Qur'an. Brain stem death (brain dead) is controversial in Islam. This, along with burial customs of Muslims being they have to be buried within 24 hours of death makes if difficult for organ donation.[12]
Christianity
editGenerally Christianity approves of organ donation although some Christians believe principle healing is achieved through prayer. The majority of Christians see organ donation as Christian love or an act of devotion to God and mankind.[12]
Judaism
editThe Jewish faith places great significance on avoiding unnecessary interference with cadavers and receiving benefit from a cadaver is prohibited. The body must also be buried within 24 hours of death. It is custom in Judaism to not interfere with death; organ donation procedures may be part of this. Only 8% of the Israel population are registered organ donors.[12]
Hinduism
editHindu's believe in reincarnation and the good deeds of one's current lifetime will determine the fate of the next lifetime. Organ donation is seen as a good deed. Hasmukh Velji Shah of the World Council of Hindus stated "The import issue for Hindu is that which sustains life should be accepted and promoted as Dharma (righteous living). Organ donation is an integral part of our living."[12]
Buddhism
editBuddhists believe in rebirth. Brain death is also controversial for Buddhists as they believe the spirit remains in the body days after death and interfering with the body may affect a person's next rebirth. However, selfless giving is integral to Buddhism; therefore organ donation is up to the individual.[12]
Donor rates in Australia
editAustralian donor rates are on the rise. Between 2009 and 2013, donor numbers increased by 29%. In 2009 there were 11.4 donors per million population. By 2013 there were 16.9 donors per million population. (Table 1.3). In Australia around 1600 people are on the organ transplant waiting list at any time. Less than 1% of persons whose death is in hospital can be potential donors because of the limited circumstances for which organ donation is possible.[13] In 2013 only 40% of patients on the organ waiting list received a transplant and 2% of the patients on the waiting list died while waiting for an organ.[14]
Table 1.3: Donor rates in Australia per million population
editReference:[15]
| Year | Organ donors
per million population |
Organ transplant recipients
per million population |
Organs transplanted
per million population |
|---|---|---|---|
| 2009 | 11.4 | 37.2 | 39.5 |
| 2010 | 14 | 42.8 | 45.1 |
| 2011 | 15.1 | 45.2 | 47.3 |
| 2012 | 15.6 | 46.3 | 48.8 |
| 2013 | 16.9 | 48.5 | 50.9 |
Table 1.4. Transplanted organs 2014 in Australia
editReference:[15]
| Organ | Number |
|---|---|
| Kidneys | 659 |
| Livers | 237 |
| Hearts | 79 |
| Heart/Lungs | 4 |
| Lungs | 159 |
| Pancreas (including pancreas islets) | 54 |
| Total | 1,193 |
Australian Organ Donor Register
editThe Australian Organ Donor Register is a government register. People can register to be organ donors or they can register that they wish to not be an organ donor. The register is nationwide and is the only register in Australia. Registering can be done online at the Donate Life website.
References
edit- ^ a b Wilkinson, K.; Peet, D. (2014). "Organ donation". InnovAiT. 7 (2): 109–116. doi:10.1177/1755738013506565. S2CID 208183197.
- ^ a b "History of organ and tissue donation (2009)". Australian Government Organ and Tissue Donation and Transplantation Authority. Retrieved 31 August 2015.
- ^ a b c d "Organ and tissue donation by living donors, guidelines for ethical practice for health professionals (2007)". Australian Government National Health and Medical Research Council. Retrieved 31 August 2015.
- ^ a b c "Organ Donation (2015)". Encyclopædia Britannica. Retrieved 31 August 2015.
- ^ a b Van Raemdonck, D.E.M., Rega, F.R., Neyrinck, A.P., Jannis, N., Verledenn, G.M., and Lerut, T.E. (2004). "Non heart beating donors". Seminars in Thoracic and Cardiovascular Surgery. 16 (4): 309–321. doi:10.1053/j.semtcvs.2004.09.014. PMID 15635535.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Organ Donation". U.S. Department of Health and Human Services. Retrieved 31 August 2015.
- ^ "Organ and Tissue Donation Frequently Asked Questions". NSW Government Health. Retrieved 31 August 2015.
- ^ Delriviere, L.; Boronovskis, H. (2011). "Adopting an Opt-Out Registration System for Organ and Tissue Donation in Western Australia". Parliament of Western Australia. Retrieved 31 August 2015.
- ^ a b Coppen, R., Friele. R.D., Marquet, R.L. and Gevers, S.K.M. (2005). "Opting-out systems: No guarantee for higher donation rates". Transplant International. 18 (11): 1275–1279. doi:10.1111/j.1432-2277.2005.00202.x. PMID 16221158.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Perry, A.G.; Potter, P.A. (2004). Clinical nursing skills and techniques (5th ed.). St.louis, Missouri: Mosby/Elsevier. p. 1254.
- ^ "Organ and tissue donation policy". Australian Medical Students Association. Retrieved 31 August 2015.[permanent dead link]
- ^ a b c d e Oliver, M., Woywodt, A., Ahmed, A., and Saif, I. (2011). "Organ donation, transplantation and religion". Nephrology, Dialysis, Transplantation. 26 (2): 437–444. doi:10.1093/ndt/gfq628. PMID 20961891.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "2013-2014 Annual Report". Australian Government Organ and Tissue Donation and Transplantation Authority. 2014. Retrieved 31 August 2015.
- ^ "Patients Listed for Solid Organ Transplantation Statistics 2013". Australian Government Organ and Tissue Donation and Transplantation Authority. 2013. Retrieved 31 August 2015.
- ^ a b Australian Government Organ and Tissue Donation and Transplantation Authority (2014). Annual Report.