OHC can refer to:
- Ocean heat content, the thermal energy held in the oceans
- Oetker Hotel Management GmbH, a German hotel management company also known as Oetker Collection
- Ohio Heritage Conference, a high school athletic league in Ohio, U.S.
- Ontario Health Coalition, an organization that advocates publicly funded health care in Ontario, Canada
- Open House Chicago, a festival in Chicago, Illinois, U.S.
- Outer hair cell, a component in the mammalian cochlear amplifier
- Overhead cam, a component in a particular location in an overhead camshaft engine