OPN may stand for:
- Osteopontin, a glycoprotein secreted by osteoblasts
- Object Process Network, a simulation model meta-language
- Optics & Photonics News, a magazine
- Oneohtrix Point Never, recording alias of musician Daniel Lopatin
- Olivary pretectal nucleus, a nucleus in the pretectal area, or pretectum
- In mathematics, odd perfect number
- Ora pro Nobis, Latin phrase litt. meaning "pray for us", often abbreviated as OpN in prayer books and breviaries
- FM Operator Type-N, a series of sound chips made by Yamaha:
This disambiguation page lists articles associated with the title OPN.
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