OMG (gene)

Oligodendrocyte-myelin glycoprotein is a protein that in humans is encoded by the OMG gene.

OMG
Identifiers
Aliases	OMG, OMGP, oligodendrocyte myelin glycoprotein
External IDs	OMIM: 164345; MGI: 106586; HomoloGene: 36099; GeneCards: OMG; OMA:OMG - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 46.79 cM Start 79,391,808 bp End 79,394,910 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell postcentral gyrus external globus pallidus Pons Brodmann area 46 corpus callosum middle frontal gyrus subthalamic nucleus orbitofrontal cortex inferior ganglion of vagus nerve Top expressed in anterior horn of spinal cord deep cerebellar nuclei globus pallidus lateral geniculate nucleus primary visual cortex superior frontal gyrus medial dorsal nucleus lumbar subsegment of spinal cord primary motor cortex piriform cortex More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 4974 18377 Ensembl n/a ENSMUSG00000049612 UniProt P23515 Q63912 RefSeq (mRNA) NM_002544 NM_019409 RefSeq (protein) NP_002535 NP_062282 Location (UCSC) n/a Chr 11: 79.39 – 79.39 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Oligodendrocyte
• Myelin
• Glycoprotein

Further reading

• Mikol DD, Gulcher JR, Stefansson K (1990). "The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate". J. Cell Biol. 110 (2): 471–9. doi:10.1083/jcb.110.2.471. PMC 2116011. PMID 1688857.
• Mikol DD, Stefansson K (1988). "A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes". J. Cell Biol. 106 (4): 1273–9. doi:10.1083/jcb.106.4.1273. PMC 2115011. PMID 3283151.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Mikol DD, Rongnoparut P, Allwardt BA, et al. (1993). "The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure". Genomics. 17 (3): 604–10. doi:10.1006/geno.1993.1379. PMID 8244377.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang KC, Koprivica V, Kim JA, et al. (2002). "Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth". Nature. 417 (6892): 941–4. doi:10.1038/nature00867. PMID 12068310. S2CID 5734715.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vourc'h P, Moreau T, Arbion F, et al. (2003). "Oligodendrocyte myelin glycoprotein growth inhibition function requires its conserved leucine-rich repeat domain, not its glycosylphosphatidyl-inositol anchor". J. Neurochem. 85 (4): 889–97. doi:10.1046/j.1471-4159.2003.01764.x. PMID 12716421. S2CID 30250786.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Venturin M, Moncini S, Villa V, et al. (2007). "Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation" (PDF). Neurogenetics. 7 (1): 59–66. doi:10.1007/s10048-005-0026-9. hdl:2434/10108. PMID 16425041. S2CID 24738309.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.