Naomi Chayen is a biochemist and structural biologist. She is a professor of Biomedical Sciences at Imperial College London, where she leads the Crystallization Group in Computational and Systems Medicine. She is best known for developing the microbatch method and inventing novel nucleants for protein crystallization which have been applied to high-throughput screening for rational drug design.
Naomi Chayen | |
|---|---|
| Education | |
| Known for | Innovations in protein crystallization methodology |
| Scientific career | |
| Fields | Structural biology |
| Institutions | Imperial College London |
| Thesis | Studies on stimulus-response coupling in smooth muscle (1983) |
Education and career
editChayen earned her first degree in pharmacy at the Hebrew University of Jerusalem. During her undergraduate studies, she visited the Kennedy Institute of Rheumatology to learn histochemistry. She subsequently pursued MSc and PhD research at the Kennedy Institute.[1] In 1983, Chayen submitted her thesis on stimulus-response coupling in smooth muscle cells and received a PhD from Brunel University London.[2]
Chayen began her first postdoctoral fellowship at Imperial College London, where she studied the biophysics of muscle proteins. When her grant was not renewed, she joined the lab of David Mervyn Blow to develop novel protein crystallization techniques. There, she began her influential work of utilizing phase diagrams to optimize conditions for crystal growth.[1]
Currently, Chayen is a professor of Biomedical Sciences and head of the Crystallization Group in Computational and Systems Medicine at Imperial College London.[3]
Research
editChayen is best known for her invention of novel protein crystallization methods. In 1990, she first published a method of suspending droplets of protein solution and precipitant solutions in low-density paraffin oil to prevent evaporation during the microbatch crystallization process. The microbatch process can be suitable for membrane proteins, which are ordinarily difficult to crystallize.[1] Chayen's method has since been applied towards the analysis of many biomolecules that are relevant to human diseases such as cancer, HIV, diabetes, and heart disease.[4]
In addition to her work on microbatch methods, Chayen invented a novel gel-glass nucleant now known as "Naomi's Nucleant."[5] Naomi's Nucleant has been used to crystallize more than 20 proteins, the most of any single nucleant.[1] In 2015, she collaborated with Subrayal Reddy at University of Central Lancashire to develop the first non-protein nucleant, a semi-liquid molecularly imprinted polymer designed for high-throughput screening. The nucleant was commercialized as "Chayen Reddy MIP."[6]
Chayen's current research interests include protein crystallization, structural biology, and structural genomics and proteomics.[3]
Awards and honors
editChayen holds nine patents and has launched several commercial products for protein crystallization, such as "Chayen Reddy MIP" and "Naomi's nucleant."[3] In addition, she has won the following awards:
- Women of Outstanding Achievement for Innovation and Entrepreneurship Commendation, WISE Campaign (2012)[7]
- Investigator of the Year, Select Biosciences Life Sciences Awards (2011)[8]
- Innovator of the Year, CWT everywoman in Technology Awards (2011)[9]
Chayen was the Sterling Drug Visiting Professor of Pharmacology at Yale School of Medicine in 2009.[10] She was formerly[when?] the president of the International Organization for Biological Crystallization.[3]
References
edit- ^ a b c d Sansom, Clare (5 March 2019). "The protein crystallisation influencer". Retrieved 2020-06-17.
- ^ Chayen, E. N. (1983). "Studies on stimulus-response coupling in smooth muscle". British Library EThOS. Retrieved 2020-06-17.
- ^ a b c d "Professor Naomi Chayen". Imperial College London. Retrieved 2020-06-17.
- ^ "Prof Naomi Chayen". London Centre for Nanotechnology. Retrieved 2020-06-17.
- ^ Chayen NE, Saridakis E, Sear RP (17 Jan 2006). "Experiment and theory for heterogeneous nucleation of protein crystals in a porous medium". PNAS. 103 (3): 597–601. doi:10.1073/pnas.0504860102. PMC 1334630.
- ^ Chayen, Naomi (17 March 2015). "'Chayen Reddy MIP' – First Non-protein Nucleating Agent Made Specifically for Robotic Crystallisation". FoM Staff Blog. Imperial College London. Retrieved 2020-06-17.
- ^ Fulford, Sima (3 December 2020). "Women in Science and Engineering (WISE)". Imperial College London. Retrieved 2020-06-17.
- ^ "Select Biosciences Release: Science and Innovation Celebrated at ELA with the Life Science Awards". 6 July 2011. Retrieved 2020-06-17.
- ^ Williams, Jenny (23 March 2011). "The winners: CWT Everywoman in Technology awards 2011". Retrieved 2020-06-17.
- ^ "Naomi Chayen, Ph.D. Professor of Bio-Molecular Medicine, Imperial College London, has been named the Sterling Drug Visiting Professor of Pharmacology". 22 June 2009. Retrieved 2020-06-17.