In molecular biology mir-5 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-5 has been implicated in regulation of VEGF in an experiment where a plasmid containing a cluster of mir-5, mir-10 and mir-7 was shown to down-regulate VEGF by 75%.[1] mir-5 in chicken has been implicated in targeting genes involved in metabolism.[2]
| mir-5 | |
|---|---|
| Identifiers | |
| Symbol | mir-5 |
| Rfam | RF00854 |
| miRBase family | 2 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
See also
editExternal links
edit- ^ Pihlmann M, Askou AL, Aagaard L, Bruun GH, Svalgaard JD, Holm-Nielsen MH, Dagnaes-Hansen F, Bek T, Mikkelsen JG, Jensen TG, Corydon TJ (May 2012). "Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo". The Journal of Gene Medicine. 14 (5): 328–38. doi:10.1002/jgm.2623. PMID 22438271. S2CID 34222199.
- ^ Hicks JA, Trakooljul N, Liu HC (April 2010). "Discovery of chicken microRNAs associated with lipogenesis and cell proliferation". Physiological Genomics. 41 (2): 185–93. doi:10.1152/physiolgenomics.00156.2009. PMID 20103699.
External links
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