MORC3

MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.

MORC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QQ4
Identifiers
Aliases	MORC3, NXP2, ZCW5, ZCWCC3, MORC family CW-type zinc finger 3
External IDs	OMIM: 610078; MGI: 2136841; HomoloGene: 32257; GeneCards: MORC3; OMA:MORC3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.12 Start 36,320,189 bp End 36,386,148 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C4 Start 93,629,009 bp End 93,672,961 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon paraflocculus of cerebellum middle frontal gyrus epithelium of nasopharynx epithelium of colon Brodmann area 10 mucosa of paranasal sinus frontal pole gingival epithelium palpebral conjunctiva Top expressed in spermatocyte primitive streak lymph node otic placode mesenteric lymph nodes granulocyte tail of embryo genital tubercle conjunctival fornix otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding RNA binding protein binding Cellular component nuclear matrix PML body nucleus nucleoplasm Biological process protein phosphorylation protein stabilization viral process negative regulation of fibroblast proliferation post-embryonic development peptidyl-serine phosphorylation maintenance of protein location in nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23515 338467 Ensembl ENSG00000159256 ENSMUSG00000039456 UniProt Q14149 F7BJB9 RefSeq (mRNA) NM_015358 NM_001320445 NM_001320446 NM_001045529 RefSeq (protein) NP_001307374 NP_001307375 NP_056173 NP_001038994 Location (UCSC) Chr 21: 36.32 – 36.39 Mb Chr 16: 93.63 – 93.67 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.

See also

• Zinc finger

Further reading

• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Kimura Y, Sakai F, Nakano O, et al. (2002). "The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains". J. Biol. Chem. 277 (23): 20611–7. doi:10.1074/jbc.M201440200. PMID 11927593.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rosendorff A, Sakakibara S, Lu S, et al. (2006). "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5308–13. Bibcode:2006PNAS..103.5308R. doi:10.1073/pnas.0601066103. PMC 1459351. PMID 16567619.
• Takahashi K, Yoshida N, Murakami N, et al. (2007). "Dynamic regulation of p53 subnuclear localization and senescence by MORC3". Mol. Biol. Cell. 18 (5): 1701–9. doi:10.1091/mbc.E06-08-0747. PMC 1855011. PMID 17332504.