MCAD may refer to:
Science and technology
edit- ACADM or MCAD, a gene
- Medium-chain acyl-CoA dehydrogenase, an enzyme used in lipid metabolism
- Medium-chain acyl-coenzyme A dehydrogenase deficiency (MCAD deficiency or MCADD), caused by mutations in the ACADM gene
- Mast cell activation disorder, a disease
- Microsoft Certified Application Developer
- Mechanical computer-aided design