Lycopene β-cyclase (EC 5.5.1.19, CrtL, CrtL-b, CrtY) is an enzyme with systematic name carotenoid beta-end group lyase (decyclizing).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
| Lycopene β-cyclase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.5.1.19 | ||||||||
| CAS no. | 220801-82-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- carotenoid ψ-end group carotenoid β-end group
This enzyme requires NAD(P)H. It converts Lycopene (2 ψ ends) into β-carotene (2 β ends).
References
edit- ^ Cunningham FX, Chamovitz D, Misawa N, Gantt E, Hirschberg J (August 1993). "Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene". FEBS Letters. 328 (1–2): 130–8. doi:10.1016/0014-5793(93)80980-9. PMID 8344419. S2CID 86704801.
- ^ Cunningham FX, Sun Z, Chamovitz D, Hirschberg J, Gantt E (August 1994). "Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942". The Plant Cell. 6 (8): 1107–21. doi:10.1105/tpc.6.8.1107. JSTOR 3869889. PMC 160505. PMID 7919981.
- ^ Hugueney P, Badillo A, Chen HC, Klein A, Hirschberg J, Camara B, Kuntz M (September 1995). "Metabolism of cyclic carotenoids: a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts". The Plant Journal. 8 (3): 417–24. doi:10.1046/j.1365-313x.1995.08030417.x. PMID 7550379.
- ^ Pecker I, Gabbay R, Cunningham FX, Hirschberg J (February 1996). "Cloning and characterization of the cDNA for lycopene beta-cyclase from tomato reveals decrease in its expression during fruit ripening". Plant Molecular Biology. 30 (4): 807–19. doi:10.1007/bf00019013. PMID 8624411. S2CID 10470698.
- ^ Hornero-Méndez D, Britton G (March 2002). "Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis". FEBS Letters. 515 (1–3): 133–6. doi:10.1016/s0014-5793(02)02453-5. PMID 11943208. S2CID 25408239.
- ^ Maresca JA, Graham JE, Wu M, Eisen JA, Bryant DA (July 2007). "Identification of a fourth family of lycopene cyclases in photosynthetic bacteria". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11784–9. doi:10.1073/pnas.0702984104. PMC 1905924. PMID 17606904.
External links
edit- Lycopene+beta-cyclase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
