Lori Anne Passmore FRS is a Canadian/British cryo electron microscopist and structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge.[3][4] She is known for her work on multiprotein complexes involved in gene expression[5][6][7] and development of new supports for cryo-EM.[8]
Lori Passmore | |
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| Born | Lori Anne Passmore |
| Nationality | Canadian/British |
| Alma mater | |
| Awards |
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| Scientific career | |
| Fields | |
| Institutions | |
| Thesis | Structural and functional studies of the anaphase promoting complex (APC) (2003) |
| Doctoral advisor | David Barford |
| Other academic advisors | Venki Ramakrishnan Richard Henderson |
| Website | www2 |
Education
editLori Passmore graduated from the University of British Columbia, Canada in 1999.[9] She obtained a PhD in 2003 from University of London for research supervised by David Barford at the Institute of Cancer Research. She performed in vitro biochemical characterisation of the activity of the anaphase-promoting complex (APC)[10] and used cryo-EM to study the APC structure.[2][11]
Career and research
editPassmore worked as a postdoctoral researcher at the MRC-LMB. She worked with Venki Ramakrishnan and Richard Henderson, using cryo-EM to determine the structure of the eukaryotic ribosome bound to initiation factors.[12] Passmore became a group leader at the MRC-LMB in 2009. Her group uses in vitro reconstitution, biochemical assays and cryo-EM to understand the function of multiprotein complexes that regulate gene expression at the level of mRNA.[5][6][7] Her group has developed new sample grids for cryo-EM that reduce specimen movement during imaging.[8] In collaboration with Ketan J. Patel, Passmore is also actively studying the molecular mechanisms underlying Fanconi anemia.[13][14]
Grants, awards and honours
edit- 2005 Beit Memorial Fellowship for Medical Research[9]
- 2009 Fellow of Clare Hall, Cambridge[15]
- 2010 European Research Council (ERC) starting grant[9]
- 2015 EMBO Young Investigator Program[16][17]
- 2016 Suffrage Science award[1]
- 2017 ERC consolidator grant[9][18]
- 2018 Member, European Molecular Biology Organisation (EMBO)[19][20]
- 2023 Elected Fellow of the Royal Society[21]
References
edit- ^ a b "Celebrating women in science on Ada Lovelace Day 2016". suffragescience.org. Retrieved 2018-06-08.
- ^ a b Passmore, Lori Anne (2003). Structural and functional studies of the anaphase promoting complex (APC). london.ac.uk (PhD thesis). University Of London. OCLC 500247667. EThOS uk.bl.ethos.406167.
- ^ Lori Passmore publications indexed by Google Scholar
- ^ Lori Passmore publications from Europe PubMed Central
- ^ a b Wolf J, Valkov E, Allen MD, Meineke B, Gordiyenko Y, McLaughlin SH, Olsen TM, Robinson CV, Bycroft M, Stewart M, Passmore LA (2014). "Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation". The EMBO Journal. 33 (14): 1514–26. doi:10.15252/embj.201488373. PMC 4158885. PMID 24872509.
- ^ a b Casañal A, Kumar A, Hill CH, Easter AD, Emsley P, Degliesposti G, Gordiyenko Y, Santhanam B, Wolf J, Wiederhold K, Dornan GL, Skehel M, Robinson CV, Passmore LA (2017). "Architecture of eukaryotic mRNA 3'-end processing machinery". Science. 358 (6366): 1056–1059. doi:10.1126/science.aao6535. PMC 5788269. PMID 29074584.
- ^ a b Stowell JA, Webster MW, Kögel A, Wolf J, Shelley KL, Passmore LA (2016). "Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1". Cell Reports. 17 (8): 1978–1989. doi:10.1016/j.celrep.2016.10.066. PMC 5120349. PMID 27851962.
- ^ a b Russo CJ, Passmore LA (2014). "Electron microscopy: Ultrastable gold substrates for electron cryomicroscopy". Science. 346 (6215): 1377–80. doi:10.1126/science.1259530. PMC 4296556. PMID 25504723.
- ^ a b c d "Dr. Lori Anne Passmore - AcademiaNet". www.academia-net.org. Retrieved 2018-06-08.
- ^ Passmore LA, McCormack EA, Au SW, Paul A, Willison KR, Harper JW, Barford D (2003). "Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition". The EMBO Journal. 22 (4): 786–96. doi:10.1093/emboj/cdg084. PMC 145444. PMID 12574115.
- ^ Passmore LA, Booth CR, Vénien-Bryan C, Ludtke SJ, Fioretto C, Johnson LN, Chiu W, Barford D (2005). "Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation". Molecular Cell. 20 (6): 855–66. doi:10.1016/j.molcel.2005.11.003. PMID 16364911.
- ^ Passmore LA, Schmeing TM, Maag D, Applefield DJ, Acker MG, Algire MA, Lorsch JR, Ramakrishnan V (2007). "The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome". Molecular Cell. 26 (1): 41–50. doi:10.1016/j.molcel.2007.03.018. PMID 17434125.
- ^ Rajendra E, Garaycoechea JI, Patel KJ, Passmore LA (2014). "Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases". Nucleic Acids Research. 42 (22): 13736–13748. doi:10.1093/nar/gku1230. PMC 4267650. PMID 25428364.
- ^ Rajendra E, Oestergaard VH, Langevin F, Wang M, Dornan GL, Patel KJ, Passmore LA (2014). "The Genetic and Biochemical Basis of FANCD2 Monoubiquitination". Molecular Cell. 54 (5): 858–869. doi:10.1016/j.molcel.2014.05.001. PMC 4051986. PMID 24905007.
- ^ "Dr Lori A Passmore | Clare Hall". www.clarehall.cam.ac.uk. Retrieved 2018-06-08.
- ^ "Twenty-seven researchers named as EMBO Young Investigators". EMBO. 2018. Retrieved 2018-06-08.
- ^ EMBO - excellence in life sciences (2017-03-15), Meet EMBO Young Investigator - Lori Passmore, retrieved 2018-06-08
- ^ "List of ERC consolidator grant awardees 2016" (PDF).
- ^ EMBO. "62 life scientists elected as EMBO Members". EMBO. Retrieved 2018-06-08.
- ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 2018-06-08.
- ^ "Hanadi Sleiman". royalsociety.org. Retrieved 2023-05-24.
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