These hits topped the Ultratop 50 in the Flanders region of Belgium in 1981.[1]
| Issue date | Song | Artist |
|---|---|---|
| 3 January | "Santa Maria" | Roland Kaiser |
| 10 January | ||
| 17 January | ||
| 24 January | ||
| 31 January | ||
| 7 February | "Lola (Live)" | The Kinks |
| 14 February | "Stars on 45" | Stars on 45 |
| 21 February | ||
| 28 February | "Shine Up" | Doris D and the Pins |
| 7 March | "Stars on 45" | Stars on 45 |
| 14 March | ||
| 21 March | ||
| 28 March | ||
| 4 April | "Shaddap You Face" | Joe Dolce Musical Theatre |
| 11 April | ||
| 18 April | ||
| 25 April | "Vienna" | Ultravox |
| 2 May | ||
| 9 May | ||
| 16 May | "Making Your Mind Up" | Bucks Fizz |
| 23 May | ||
| 30 May | ||
| 6 June | "Can You Feel It" | The Jacksons |
| 13 June | "How 'Bout Us" | Champaign |
| 20 June | ||
| 27 June | "I've Seen That Face Before (Libertango)" | Grace Jones |
| 4 July | ||
| 11 July | ||
| 18 July | "Only Crying" | Keith Marshall |
| 25 July | ||
| 1 August | ||
| 8 August | ||
| 15 August | "Caribbean Disco Club" | Lobo |
| 22 August | ||
| 29 August | "One Day in Your Life" | Michael Jackson |
| 5 September | ||
| 12 September | "Wordy Rappinghood" | Tom Tom Club |
| 19 September | "One Day in Your Life" | Michael Jackson |
| 26 September | ||
| 3 October | "Japanese Boy" | Aneka |
| 10 October | ||
| 17 October | "Why Tell Me Why" | Anita Meyer |
| 24 October | ||
| 31 October | ||
| 7 November | ||
| 14 November | "Tainted Love" | Soft Cell |
| 21 November | ||
| 28 November | ||
| 5 December | "Physical" | Olivia Newton-John |
| 12 December | "Pretend" | Alvin Stardust |
| 19 December | ||
| 26 December | "Why Do Fools Fall in Love" | Diana Ross |