This list is for original fictional characters created for adaptations of comic books in other forms of media (television series, films, books, games and advertising).
It includes characters like Firestar and X-23 that were later incorporated into mainstream comics. The category does not include preexisting characters from fiction (books, film, television, etc.) such as Dracula, Conan or Rima that were later incorporated into comics. Characters unique to certain movies and television programs such as Rachel Dawes and Max Shreck are not included on this list because they do not have counterparts in any mainstream comic book.
- Apache Chief
- Andrea Beaumont
- Ethan Bennett
- Black Vulcan
- Cinderblock
- Alex Danvers
- John Diggle
- El Dorado
- Egghead
- Nora Fries
- Gleek
- Gray Ghost
- Mercy Graves
- Inspector William Henderson
- Inque
- Isis
- Aqualad (Kaldur'ahm)
- Livewire
- Lock-Up
- Lionel Luthor
- Más y Menos
- Batman (Terry McGinnis)
- Renee Montoya
- Music Meister
- Non
- Jimmy Olsen
- Harley Quinn
- Red X
- Roxy Rocket
- Samurai
- Chloe Sullivan
- King Tut
- Ursa
- Superwoman (Kristin Wells)
- Wendy and Marvin
- Perry White
- Wonder Twins
- Baby Doll