Lafadofensine (INNTooltip International Nonproprietary Name), also known as (3S)-N,N-bis(4-fluorophenyl)pyrrolidin-3-amine, is a drug described as an antidepressant which has not been marketed at this time.[1][2][3] It is said to act as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI).[1] The drug was first described by 2010[4] and its INNTooltip International Nonproprietary Name was proposed by 2021.[5]

Lafadofensine
Clinical data
Drug classSerotonin–norepinephrine–dopamine reuptake inhibitor
Identifiers
  • (3S)-N,N-bis(4-fluorophenyl)pyrrolidin-3-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC16H16F2N2
Molar mass274.315 g·mol−1
3D model (JSmol)
  • C1CNC[C@H]1N(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
  • InChI=1S/C16H16F2N2/c17-12-1-5-14(6-2-12)20(16-9-10-19-11-16)15-7-3-13(18)4-8-15/h1-8,16,19H,9-11H2/t16-/m0/s1
  • Key:ZKEVVJGPWXTETN-INIZCTEOSA-N

See also

edit

References

edit
  1. ^ a b World Health Organization (2024). "Use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances, 2024" (PDF). World Health Organization. p. 102. Retrieved 21 October 2024. -fensine norepinephrine, serotonin, dopamine reuptake inhibitors brasofensine (76), diclofensine (44), lafadofensine (126), liafensine (109), nomifensine (24), perafensine (44), tesofensine (89)
  2. ^ "LAFADOFENSINE". Inxight Drugs. Retrieved 21 October 2024.
  3. ^ "Lafadofensine". PubChem. Retrieved 21 October 2024.
  4. ^ "N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors". Google Patents. 10 June 2010. Retrieved 21 October 2024.
  5. ^ https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl126.pdf