LIN7C

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.

LIN7C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LRA
Identifiers
Aliases	LIN7C, LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3, lin-7 homolog C, crumbs cell polarity complex component
External IDs	OMIM: 612332; MGI: 1330839; HomoloGene: 22649; GeneCards: LIN7C; OMA:LIN7C - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p14.1 Start 27,494,418 bp End 27,506,769 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 E3|2 56.65 cM Start 109,721,198 bp End 109,731,348 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus germinal epithelium epithelium of nasopharynx retinal pigment epithelium tibia oral cavity Brodmann area 23 visceral pleura parietal pleura kidney tubule Top expressed in olfactory epithelium lobe of cerebellum medial ganglionic eminence median eminence pineal gland cerebellar vermis zygote tail of embryo dentate gyrus superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding cytoskeletal protein binding L27 domain binding PDZ domain binding Cellular component cytoplasm postsynaptic membrane postsynaptic density membrane cell-cell junction bicellular tight junction plasma membrane MPP7-DLG1-LIN7 complex cell junction basolateral plasma membrane neuron projection presynapse synapse glutamatergic synapse Biological process protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport morphogenesis of an epithelial sheet neurotransmitter secretion exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55327 22343 Ensembl ENSG00000148943 ENSMUSG00000027162 UniProt Q9NUP9 O88952 RefSeq (mRNA) NM_018362 NM_011699 RefSeq (protein) NP_060832 NP_035829 Location (UCSC) Chr 11: 27.49 – 27.51 Mb Chr 2: 109.72 – 109.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

LIN7C has been shown to interact with:

• DLG1,
• KCNJ12, and
• KCNJ4.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P (2002). "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332–42. doi:10.1093/emboj/21.10.2332. PMC 126011. PMID 12006486.
• Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. Bibcode:2003FEBSL.554...30H. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
• Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA (2006). "A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes". J. Biol. Chem. 280 (46): 38528–36. doi:10.1074/jbc.M506536200. PMID 16147993.
• Mendes CC, Gomes DA, Thompson M, Souto NC, Goes TS, Goes AM, Rodrigues MA, Gomez MV, Nathanson MH, Leite MF (2006). "The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria". J. Biol. Chem. 280 (49): 40892–900. doi:10.1074/jbc.M506623200. PMID 16192275.
• Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J. Biol. Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
• Onda T, Uzawa K, Nakashima D, Saito K, Iwadate Y, Seki N, Shibahara T, Tanzawa H (2007). "Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma" (PDF). Cancer Res. 67 (20): 9643–8. doi:10.1158/0008-5472.CAN-07-1911. hdl:10130/633. PMID 17942893.