LGR4

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

LGR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KT1, 4QXE, 4QXF
Identifiers
Aliases	LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4, DPSL
External IDs	OMIM: 606666; MGI: 1891468; HomoloGene: 10226; GeneCards: LGR4; OMA:LGR4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p14.1 Start 27,365,961 bp End 27,472,790 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E3 Start 109,747,992 bp End 109,844,602 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas hair follicle gingival epithelium rectum decidua mucosa of colon mucosa of sigmoid colon Epithelium of choroid plexus metanephros metanephric glomerulus Top expressed in hand otolith organ epithelium of lens utricle renal corpuscle ciliary body Gonadal ridge left colon epithelium of stomach migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding transmembrane signaling receptor activity G protein-coupled receptor activity protein-hormone receptor activity G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane Biological process hair follicle development G protein-coupled receptor signaling pathway cell differentiation positive regulation of branching involved in ureteric bud morphogenesis male genitalia development metanephric nephron tubule morphogenesis rhythmic process metanephric glomerulus development immune system process epithelial cell proliferation Wnt signaling pathway tube morphogenesis positive regulation of transcription, DNA-templated multicellular organism development cell differentiation involved in metanephros development intestinal stem cell homeostasis epithelial cell proliferation involved in renal tubule morphogenesis circadian rhythm canonical Wnt signaling pathway involved in metanephric kidney development digestive tract development innate immune response negative regulation of transcription, DNA-templated signal transduction positive regulation of canonical Wnt signaling pathway bone remodeling circadian regulation of gene expression spermatogenesis osteoblast differentiation bone mineralization negative regulation of toll-like receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway activation of adenylate cyclase activity hormone-mediated signaling pathway negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55366 107515 Ensembl ENSG00000205213 ENSMUSG00000050199 UniProt Q9BXB1 A2ARI4 RefSeq (mRNA) NM_018490 NM_001346432 NM_172671 RefSeq (protein) NP_001333361 NP_060960 NP_766259 Location (UCSC) Chr 11: 27.37 – 27.47 Mb Chr 2: 109.75 – 109.84 Mb PubMed search
Wikidata
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Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

Further reading

• Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
• Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID 11401528.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.