Jumping translocation breakpoint

The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene. It is an orphan receptor with unknown function.

JTB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KJX
Identifiers
Aliases	JTB, HHSPC222, PAR, hJT, jumping translocation breakpoint
External IDs	OMIM: 604671; MGI: 1346082; HomoloGene: 4870; GeneCards: JTB; OMA:JTB - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 153,974,269 bp End 153,977,674 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 90,138,904 bp End 90,143,145 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of ileum mucosa of sigmoid colon tibia pancreatic ductal cell body of pancreas skin of thigh pituitary gland anterior pituitary Epithelium of choroid plexus Top expressed in parotid gland Ileal epithelium saccule seminal vesicula Paneth cell lacrimal gland epithelium of lens triceps brachii muscle sternocleidomastoid muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding Cellular component cytoplasm integral component of membrane centrosome spindle midbody integral component of plasma membrane cytoskeleton membrane mitochondrion microtubule organizing center Biological process apoptotic process cell division cell cycle apoptotic mitochondrial changes regulation of cell population proliferation positive regulation of protein kinase activity mitotic cell cycle mitotic cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10899 23922 Ensembl ENSG00000143543 ENSMUSG00000027937 UniProt O76095 O88824 RefSeq (mRNA) NM_006694 NM_206924 RefSeq (protein) NP_006685 NP_996807 Location (UCSC) Chr 1: 153.97 – 153.98 Mb Chr 3: 90.14 – 90.14 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Jumping translocation breakpoint protein (JTB)
Identifiers
Symbol	JTB
Pfam	PF05439
InterPro	IPR008657
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC). JTB has also been implicated in prostatic carcinomas.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wong N, Chan A, Lee SW, et al. (2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". J. Hepatol. 38 (3): 298–306. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Platica O, Chen S, Ivan E, et al. (2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein JTB

This article incorporates text from the public domain Pfam and InterPro: IPR008657