Ioffe is a Jewish surname. Notable people with the surname include:
- Abram Ioffe (1880–1960), Ukraine-born Soviet physicist
- Dmitry Ioffe (1963–2020), Israeli mathematician
- Julia Ioffe (born 1982), Russian-born American journalist
- Mikhail Ioffe (1917–1996), Soviet/Russian physicist
- Nelli Ioffe (born 2004), Russian-Israeli figure skater