Interstitial granulomatous dermatitis with arthritis (IGDA) or Ackerman dermatitis syndrome is a skin condition that most commonly presents with symmetrical round-to-oval red or violet plaques on the flanks, armpits, inner thighs, and lower abdomen.[1]
| Interstitial granulomatous dermatitis with arthritis | |
|---|---|
| Other names | Ackerman dermatitis syndrome, IGDA |
| Specialty | Dermatology |
Signs and symptoms
editInterstitial granulomatous dermatitis with arthritis commonly presents with symmetrical round-to-oval red or violet plaques on the flanks, armpits, inner thighs, and lower abdomen.[1] The arthritis that coexists with these skin lesions may develop years, months, or even years before the cutaneous lesions first manifest. The symmetrical nature of the joint involvement is evident, frequently affecting the fingers, elbows, wrists, and shoulders.[2]
Causes
editCertain medications, including beta-blockers, alpha-blockers, calcium channel blockers, hypolipidemic medications, and angiotensin-converting enzyme inhibitors, have been linked to IGDA, according to reports.[3][4][5]
Diagnosis
editAutoantibodies, elevated erythrocyte sedimentation rate (ESR), and rheumatoid factor positivity are among the abnormal serologic findings reported in the majority of IGDA patients.[6]
This entity has a unique histopathology that is characterized by a diffuse, dense inflammatory infiltrate that is primarily made up of histiocytes within the reticular dermis. Palisades are formed by small foci of histiocytes and degenerated collagen. Neutrophils and eosinophils may be found in the infiltrate in addition to other things. Vasculitis and mucin deposition are not anticipated.[2]
Treatment
editThere is still uncertainty surrounding the suggested therapies for IGDA. Corticosteroids, non-steroid anti-inflammatory medications, antimalarial medications, cyclosporine, dapsone, methotrexate, cyclophosphamide, and anti-TNK alpha are some examples of treatment options that can be applied topically or systemically.[7]
See also
editReferences
edit- ^ a b James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 180. ISBN 0-7216-2921-0.
- ^ a b Long, David; Thiboutot, Diane M; Majeski, Joseph T; Vasily, David B; Helm, Klaus F (1996). "Interstitial granulomatous dermatitis with arthritis". Journal of the American Academy of Dermatology. 34 (6). Elsevier BV: 957–961. doi:10.1016/s0190-9622(96)90272-8. ISSN 0190-9622. PMID 8647988.
- ^ Veronez, Isis Suga; Dantas, Fernando Luiz; Valente, Neusa Yuriko; Kakizaki, Priscila; Yasuda, Thaís Helena; Cunha, Thaís do Amaral (2015). "Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis". Anais Brasileiros de Dermatologia. 90 (3). FapUNIFESP (SciELO): 391–393. doi:10.1590/abd1806-4841.20153263. ISSN 0365-0596. PMC 4516102. PMID 26131871.
- ^ Worsnop, F. S.; Ostlere, L. (March 27, 2013). "Interstitial granulomatous dermatitis with arthritis presenting with the rope sign". Clinical and Experimental Dermatology. 38 (5). Oxford University Press (OUP): 564–565. doi:10.1111/ced.12052. ISSN 0307-6938. PMID 23531209. S2CID 28851504.
- ^ Antunes, Joana; Pacheco, David; Travassos, Ana Rita; Soares-Almeida, Luís Miguel; Filipe, Paulo; Sacramento-Marques, Manuel (2012). "Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis". Anais Brasileiros de Dermatologia. 87 (5). FapUNIFESP (SciELO): 748–751. doi:10.1590/s0365-05962012000500013. ISSN 0365-0596. PMID 23044569.
- ^ Verneuil, Laurence; Dompmartin, Anne; Comoz, François; Pasquier, Corinne Jeanne; Leroy, Dominique (2001). "Interstitial granulomatous dermatitis with cutaneous cords and arthritis: A disorder associated with autoantibodies". Journal of the American Academy of Dermatology. 45 (2). Elsevier BV: 286–291. doi:10.1067/mjd.2001.114577. ISSN 0190-9622. PMID 11464193.
- ^ Ucelli, Juliana Lacerda Reis; Rudolph, Fabiana de Sousa Borges; Obadia, Daniel Lago; Dionello, Carla da Fontoura (2017). "Interstitial granulomatous dermatitis with arthritis". Anais Brasileiros de Dermatologia. 92 (3). FapUNIFESP (SciELO): 434–436. doi:10.1590/abd1806-4841.20175973. ISSN 0365-0596. PMC 5514599. PMID 29186271.
Further reading
edit- CROWSON, A (2004). "Interstitial granulomatous dermatitis with arthritis". Human Pathology. 35 (7). Elsevier BV: 779–780. doi:10.1016/j.humpath.2004.05.001. ISSN 0046-8177. PMID 15257538.
- Schanz, Stefan (January 1, 2012). "Interstitial Granulomatous Dermatitis With Arthritis Responding to Tocilizumab". Archives of Dermatology. 148 (1). American Medical Association (AMA): 17–20. doi:10.1001/archdermatol.2011.341. ISSN 0003-987X. PMID 22250229.