Indacaterol/glycopyrronium bromide, sold under the brand name Ultibro Breezhaler among others, is a fixed-dose combination medication for inhalation consisting of the following two active ingredients:
- Indacaterol maleate—an ultra-long-acting beta-adrenoceptor agonist (ultra-LABA);[2]
- Glycopyrronium bromide (glycopyrrolate)—a muscarinic anticholinergic.
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| Combination of | |
|---|---|
| Indacaterol | Ultra-long-acting beta-adrenoceptor agonist |
| Glycopyrronium bromide | Muscarinic anticholinergic |
| Clinical data | |
| Trade names | Ultibro Breezhaler, Utibron Neohaler, Xoterna Breezhaler |
| Pregnancy category |
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| Routes of administration | Inhalation only |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| KEGG | |
| CompTox Dashboard (EPA) | |
Indacaterol maleate/glycopyrronium bromide is used as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).[3]
The drug is marketed by Novartis under the trade names Ultibro Breezhaler and Utibron Neohaler in Europe and the United States, respectively.[3][4] In 2016, Novartis licensed its U.S. commercial rights for Seebri Neohaler and Utibron Neohaler to Sunovion Pharmaceuticals.[5]
References
edit- ^ "Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.
- ^ Cazzola M, Matera MG, Lötvall J (July 2005). "Ultra long-acting beta 2-agonists in development for asthma and chronic obstructive pulmonary disease". Expert Opin Investig Drugs. 14 (7): 775–83. doi:10.1517/13543784.14.7.775. PMID 16022567. S2CID 11930383.
- ^ a b "Ultibro Breezhaler". medicines.org.uk. DataPharm. 3 February 2015. Retrieved 9 February 2015.
- ^ "Approval History: NDA 207930". DRUGS@FDA. US FDA. Retrieved 14 May 2016.
- ^ Faulkner, Sarah (22 December 2016). "Sunovion, Novartis ink licensing deal for inhaled COPD drugs". Drug Delivery Business.
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